Implementation of a multifaceted program to sustainably improve appropriate intraoperative antibiotic redosing

Cormac T. O'Sullivan, William Kirke Rogers, Mark Ackman, Michihiko Goto, Brian M. Hoff

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: National guidelines recommend intraoperative redosing of prophylactic antibiotics at defined intervals to reduce the risk of surgical site infections. Compliance with these guidelines is poor. Methods: A quality improvement project—including education, progress reports, and automated redosing reminders in the anesthesia electronic health record—was implemented at a large university-affiliated hospital to increase rates of intraoperative antibiotic redosing for surgeries lasting more than 4 hours. A retrospective, observational study was then conducted. The primary outcome was the compliance rate with intraoperative antibiotic redosing criteria for all surgeries lasting more than 4 hours in the pre- and post-project period. The effect of the intervention was assessed by an interrupted time-series Poisson regression model. Results: A total of 13,695 surgical procedures were evaluated. Time-series analysis demonstrated that the project was associated with significant improvement of compliance rates (incidence rate ratio [IRR]: 1.16; P =.002) with no significant change in underlying improvement trend (IRR: 1.00; P =.22). Discussion: Few peer-reviewed manuscripts describe effective methods to ensure appropriate antibiotic redosing during prolonged surgeries. We demonstrated that a multipronged approach was very effective at producing immediate and sustained improvements in guideline compliance. Conclusions: Implementation of a multifaceted intervention improved rates of guideline-concordant redosing of intraoperative prophylactic antibiotics.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalAmerican journal of infection control
Issue number1
StatePublished - Jan 2019

Bibliographical note

Funding Information:
The authors thank Bridget Moellers, DNP, CRNA, and Shannon Schoening DNP, CRNA, for their significant efforts in initiating the quality improvement project upon which this manuscript is based. We also thank Emine Bayman, PhD, for reviewing this manuscript.


  • Antibiotic redosing
  • Electronic health record
  • Perioperative prophylactic antibiotics
  • Surgical site infection

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