Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice

Guihua Xiao; Xinxia Cai; Yilin Song; Yu Zhang; Shengwei Xu; Fei Gao; Jingyu Xie; Mixia Wang; Huabing Yin; Tianhong Cui

doi:10.1109/NANO46743.2019.8993886

Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice

Guihua Xiao, Xinxia Cai, Yilin Song, Yu Zhang, Shengwei Xu, Fei Gao, Jingyu Xie, Mixia Wang, Huabing Yin, Tianhong Cui

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Millions of people are affecting by epilepsy due to the unclear pathogenesis. In this paper, we fabricated an implantable microelectrode array for spike patterns and local field potential signals detection in the hippocampus of awake epileptic mice. The abnormal epileptiform electrical signals were recorded when the mice were occurring a seizure. During a seizure, pyramidal neurons with higher amplitude appeared together with interneurons which firing intensively. The abnormal local field potential (LFP) waveform changed from the slow oscillation with low frequency and high amplitude, to the sharp-wave and spike-wave. The oscillation frequency of LFP waveform is low while amplitude is high at the beginning and ending of seizure. On the contrary, in the middle of seizure, frequency is high while amplitude is low. This detection technology provides us an effective method to understand the neuron activities at neuron level.

Original language	English (US)
Title of host publication	19th IEEE International Conference on Nanotechnology, NANO 2019
Publisher	IEEE Computer Society
Pages	153-156
Number of pages	4
ISBN (Electronic)	9781728128917
DOIs	https://doi.org/10.1109/NANO46743.2019.8993886
State	Published - Jul 2019
Event	19th IEEE International Conference on Nanotechnology, NANO 2019 - Macau, China Duration: Jul 22 2019 → Jul 26 2019

Publication series

Name	Proceedings of the IEEE Conference on Nanotechnology
Volume	2019-July
ISSN (Print)	1944-9399
ISSN (Electronic)	1944-9380

Conference

Conference	19th IEEE International Conference on Nanotechnology, NANO 2019
Country/Territory	China
City	Macau
Period	7/22/19 → 7/26/19

Bibliographical note

Funding Information:
*Reseach supported by the National Key R&D Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS. 1The State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, P.R. China. 2University of Chinese Academy of Sciences, Beijing 100049, P.R. China. 3Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, G12 8LT, UK. 4Department of Mechanical Engineering, University of Minnesota, 111 Church St. S.E., Minneapolis, MN 55455, USA †Corresponding Author E-mail: xxcai@mail.ie.ac.cn Tel: +86 010-58887193

Funding Information:
Reseach supported by the National Key RandD Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS

Funding Information:
ACKNOWLEDGMENT This work was sponsored by the National Key R&D Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS.

Publisher Copyright:
© 2019 IEEE.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Publisher link

10.1109/NANO46743.2019.8993886

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Xiao, G., Cai, X., Song, Y., Zhang, Y., Xu, S., Gao, F., Xie, J., Wang, M., Yin, H., & Cui, T. (2019). Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice. In 19th IEEE International Conference on Nanotechnology, NANO 2019 (pp. 153-156). [8993886] (Proceedings of the IEEE Conference on Nanotechnology; Vol. 2019-July). IEEE Computer Society. https://doi.org/10.1109/NANO46743.2019.8993886

Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice. / Xiao, Guihua; Cai, Xinxia; Song, Yilin et al.
19th IEEE International Conference on Nanotechnology, NANO 2019. IEEE Computer Society, 2019. p. 153-156 8993886 (Proceedings of the IEEE Conference on Nanotechnology; Vol. 2019-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xiao, G, Cai, X, Song, Y, Zhang, Y, Xu, S, Gao, F, Xie, J, Wang, M, Yin, H & Cui, T 2019, Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice. in 19th IEEE International Conference on Nanotechnology, NANO 2019., 8993886, Proceedings of the IEEE Conference on Nanotechnology, vol. 2019-July, IEEE Computer Society, pp. 153-156, 19th IEEE International Conference on Nanotechnology, NANO 2019, Macau, China, 7/22/19. https://doi.org/10.1109/NANO46743.2019.8993886

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abstract = "Millions of people are affecting by epilepsy due to the unclear pathogenesis. In this paper, we fabricated an implantable microelectrode array for spike patterns and local field potential signals detection in the hippocampus of awake epileptic mice. The abnormal epileptiform electrical signals were recorded when the mice were occurring a seizure. During a seizure, pyramidal neurons with higher amplitude appeared together with interneurons which firing intensively. The abnormal local field potential (LFP) waveform changed from the slow oscillation with low frequency and high amplitude, to the sharp-wave and spike-wave. The oscillation frequency of LFP waveform is low while amplitude is high at the beginning and ending of seizure. On the contrary, in the middle of seizure, frequency is high while amplitude is low. This detection technology provides us an effective method to understand the neuron activities at neuron level.",

author = "Guihua Xiao and Xinxia Cai and Yilin Song and Yu Zhang and Shengwei Xu and Fei Gao and Jingyu Xie and Mixia Wang and Huabing Yin and Tianhong Cui",

note = "Funding Information: *Reseach supported by the National Key R&D Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS. 1The State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, P.R. China. 2University of Chinese Academy of Sciences, Beijing 100049, P.R. China. 3Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, G12 8LT, UK. 4Department of Mechanical Engineering, University of Minnesota, 111 Church St. S.E., Minneapolis, MN 55455, USA †Corresponding Author E-mail: xxcai@mail.ie.ac.cn Tel: +86 010-58887193 Funding Information: Reseach supported by the National Key RandD Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS Funding Information: ACKNOWLEDGMENT This work was sponsored by the National Key R&D Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS. Publisher Copyright: {\textcopyright} 2019 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 19th IEEE International Conference on Nanotechnology, NANO 2019 ; Conference date: 22-07-2019 Through 26-07-2019",

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AU - Xu, Shengwei

AU - Gao, Fei

AU - Xie, Jingyu

AU - Wang, Mixia

AU - Yin, Huabing

AU - Cui, Tianhong

N1 - Funding Information: *Reseach supported by the National Key R&D Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS. 1The State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, P.R. China. 2University of Chinese Academy of Sciences, Beijing 100049, P.R. China. 3Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, G12 8LT, UK. 4Department of Mechanical Engineering, University of Minnesota, 111 Church St. S.E., Minneapolis, MN 55455, USA †Corresponding Author E-mail: xxcai@mail.ie.ac.cn Tel: +86 010-58887193 Funding Information: Reseach supported by the National Key RandD Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS Funding Information: ACKNOWLEDGMENT This work was sponsored by the National Key R&D Program of Nano Science and Technology of China (2017YFA0205902), the NSFC (No.61527815, No.61601435, No.61501426, No.31500800), and the Key Research Programs (QYZDJ-SSW-SYS015, XDA16020902) of Frontier Sciences, CAS. Publisher Copyright: © 2019 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

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N2 - Millions of people are affecting by epilepsy due to the unclear pathogenesis. In this paper, we fabricated an implantable microelectrode array for spike patterns and local field potential signals detection in the hippocampus of awake epileptic mice. The abnormal epileptiform electrical signals were recorded when the mice were occurring a seizure. During a seizure, pyramidal neurons with higher amplitude appeared together with interneurons which firing intensively. The abnormal local field potential (LFP) waveform changed from the slow oscillation with low frequency and high amplitude, to the sharp-wave and spike-wave. The oscillation frequency of LFP waveform is low while amplitude is high at the beginning and ending of seizure. On the contrary, in the middle of seizure, frequency is high while amplitude is low. This detection technology provides us an effective method to understand the neuron activities at neuron level.

AB - Millions of people are affecting by epilepsy due to the unclear pathogenesis. In this paper, we fabricated an implantable microelectrode array for spike patterns and local field potential signals detection in the hippocampus of awake epileptic mice. The abnormal epileptiform electrical signals were recorded when the mice were occurring a seizure. During a seizure, pyramidal neurons with higher amplitude appeared together with interneurons which firing intensively. The abnormal local field potential (LFP) waveform changed from the slow oscillation with low frequency and high amplitude, to the sharp-wave and spike-wave. The oscillation frequency of LFP waveform is low while amplitude is high at the beginning and ending of seizure. On the contrary, in the middle of seizure, frequency is high while amplitude is low. This detection technology provides us an effective method to understand the neuron activities at neuron level.

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Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice

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