Implantable Microelectrode Arrays for Epileptiform Electrical Signals Detection in the Awake Epileptic Mice

Guihua Xiao, Xinxia Cai, Yilin Song, Yu Zhang, Shengwei Xu, Fei Gao, Jingyu Xie, Mixia Wang, Huabing Yin, Tianhong Cui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Millions of people are affecting by epilepsy due to the unclear pathogenesis. In this paper, we fabricated an implantable microelectrode array for spike patterns and local field potential signals detection in the hippocampus of awake epileptic mice. The abnormal epileptiform electrical signals were recorded when the mice were occurring a seizure. During a seizure, pyramidal neurons with higher amplitude appeared together with interneurons which firing intensively. The abnormal local field potential (LFP) waveform changed from the slow oscillation with low frequency and high amplitude, to the sharp-wave and spike-wave. The oscillation frequency of LFP waveform is low while amplitude is high at the beginning and ending of seizure. On the contrary, in the middle of seizure, frequency is high while amplitude is low. This detection technology provides us an effective method to understand the neuron activities at neuron level.

Original languageEnglish (US)
Title of host publication19th IEEE International Conference on Nanotechnology, NANO 2019
PublisherIEEE Computer Society
Pages153-156
Number of pages4
ISBN (Electronic)9781728128917
DOIs
StatePublished - Jul 2019
Event19th IEEE International Conference on Nanotechnology, NANO 2019 - Macau, China
Duration: Jul 22 2019Jul 26 2019

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
Volume2019-July
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Conference

Conference19th IEEE International Conference on Nanotechnology, NANO 2019
CountryChina
CityMacau
Period7/22/197/26/19

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