Impaired water maze learning performance in μ-opioid receptor knockout mice

Choon Gon Jang, Seok Yong Lee, Ji Hoon Yoo, Ji Jing Yan, Dong Keun Song, Horace H. Loh, Ing K. Ho

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32 Scopus citations


Previous study has demonstrated that the lack of μ-opioid receptor decreased LTP in the dentate gyrus of the hippocampus, suggesting the possibility that the lack of μ-opioid receptor may accompany a change in learning and memory. However, no behavioral study has been undertaken to correlate LTP deficits with spatial memory impairment in μ-opioid receptor knockout mice. Therefore, the present study investigated the hypothesis that μ-opioid receptors contribute to learning and memory by using the Morris water maze, and comparing responses in wild type and μ-opioid receptor gene knockout mice. Our results indicated that μ-opioid receptor knockout mice showed a significant spatial memory impairment compared to wild type in the Morris water maze. This result suggests that the expression of μ-opioid receptor plays an important role in spatial learning and memory examined by Morris water maze.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalMolecular Brain Research
Issue number1
StatePublished - Sep 10 2003

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG3-21301-0017).


  • Learning and memory
  • Morris water maze
  • μ-Opioid receptor knockout mice


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