Impaired insulin sensitivity and maximal responsiveness in older hypertensive men

Donald R. Dengel, Richard E. Pratley, James M. Hagberg, Andrew P. Goldberg

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


This study examines the relation between blood pressure and insulin resistance in obese, sedentary middle-aged and older men. Eleven hypertensive and 17 normotensive subjects of comparable age (58.6±1.0 years, mean±SEM), percent body fat (27.7±0.7%), and maximal aerobic capacity (30.2±0.9 mL · kg-1 · min-1) participated in this study. Glucose disposal (M. milligrams per kilogram of fat-free mass per minute) determined during a three-dose hyperinsulinemic euglycemic clamp was lower in the hypertensive than normotensive subjects at the low (M at 120 pmol/m2 · min: 2.3±0.2 versus 3.2±0.3, P=.06), intermediate (M at 600 pmol/m2 · min: 8.0±0.6 versus 10.4±0.6, P=.02), and high (M at 3000 pmol/m2 · min; 13.5±0.5 versus 15.5±0.7, P=.04) insulin infusion rates. The calculated insulin concentration necessary for a half-maximal effect (EC50) was greater in the hypertensive than normotensive subjects (1164±168 versus 864±66 pmol/L, P=.03). In this population of normotensive and hypertensive men, systolic, diastolic, and mean arterial blood pressures were related to glucose disposal at these insulin infusion rates (r=-.35 to -.46, P<.05) as well as the EC50 (r=.42 to .44, P<.05). Thus, hypertensive obese, sedentary older men have a reduction in both sensitivity and maximal responsiveness to insulin that is directly related to the severity of hypertension independent of obesity and physical fitness.

Original languageEnglish (US)
Pages (from-to)320-324
Number of pages5
Issue number3
StatePublished - Mar 1994


  • aging
  • glucose clamp technique
  • hypertension, essential
  • insulin resistance


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