Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Archana Panikkar; Corey Smith; Andrew Hislop; Nick Tellam; Vijayendra Dasari; Kristin A. Hogquist; Michelle Wykes; Denis J. Moss; Alan Rickinson; Henry H. Balfour; Rajiv Khanna

doi:10.1128/JVI.01293-15

Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Archana Panikkar, Corey Smith, Andrew Hislop, Nick Tellam, Vijayendra Dasari, Kristin A. Hogquist, Michelle Wykes, Denis J. Moss, Alan Rickinson, Henry H. Balfour, Rajiv Khanna

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Abstract

Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBVspecific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

Original language	English (US)
Pages (from-to)	9137-9141
Number of pages	5
Journal	Journal of virology
Volume	89
Issue number	17
DOIs	https://doi.org/10.1128/JVI.01293-15
State	Published - 2015

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Publisher Copyright:
© 2015, American Society for Microbiology.

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Panikkar, A., Smith, C., Hislop, A., Tellam, N., Dasari, V., Hogquist, K. A., Wykes, M., Moss, D. J., Rickinson, A., Balfour, H. H., & Khanna, R. (2015). Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction. Journal of virology, 89(17), 9137-9141. https://doi.org/10.1128/JVI.01293-15

Panikkar, A, Smith, C, Hislop, A, Tellam, N, Dasari, V, Hogquist, KA, Wykes, M, Moss, DJ, Rickinson, A, Balfour, HH & Khanna, R 2015, 'Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction', Journal of virology, vol. 89, no. 17, pp. 9137-9141. https://doi.org/10.1128/JVI.01293-15

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abstract = "Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBVspecific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.",

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doi = "10.1128/JVI.01293-15",

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AU - Hislop, Andrew

AU - Tellam, Nick

AU - Dasari, Vijayendra

AU - Hogquist, Kristin A.

AU - Wykes, Michelle

AU - Moss, Denis J.

AU - Rickinson, Alan

AU - Balfour, Henry H.

AU - Khanna, Rajiv

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AB - Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBVspecific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

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Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Abstract

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