Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBVspecific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.
Bibliographical notePublisher Copyright:
© 2015, American Society for Microbiology.
Copyright 2017 Elsevier B.V., All rights reserved.