Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Archana Panikkar, Corey Smith, Andrew Hislop, Nick Tellam, Vijayendra Dasari, Kristin A. Hogquist, Michelle Wykes, Denis J. Moss, Alan Rickinson, Henry H. Balfour, Rajiv Khanna

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBVspecific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

Original languageEnglish (US)
Pages (from-to)9137-9141
Number of pages5
JournalJournal of virology
Volume89
Issue number17
DOIs
StatePublished - Jan 1 2015

Fingerprint Dive into the research topics of 'Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction'. Together they form a unique fingerprint.

  • Cite this