Abstract
Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)- associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBVspecific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.
Original language | English (US) |
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Pages (from-to) | 9137-9141 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 89 |
Issue number | 17 |
DOIs | |
State | Published - 2015 |
Bibliographical note
Publisher Copyright:© 2015, American Society for Microbiology.