Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults

Aaron R. Folsom, Hekmat T. Qamhieh, Rena R. Wing, Robert W. Jeffery, Valarie L. Stinson, Lewis H. Kuller, Kenneth K. Wu

Research output: Contribution to journalArticlepeer-review

209 Scopus citations

Abstract

Based on previous cross-sectional findings, we hypothesized that weight loss could improve several hemostatic factors associated with cardiovascular disease. In a randomized controlled trial, moderately overweight men and women were assigned to one of four weight loss treatment groups or to a control group. Measurements of plasminogen activator inhibitor-1 (PAI-1) antigen, tissue-type plasminogen activator (t-PA) antigen, D-dimer antigen, factor VII activity, fibrinogen, and protein C antigen were made at baseline and after 6 months in 90 men and 88 women. Net treatment weight loss was 9.4 kg in men and 7.4 kg in women. There was no net change (p>0.05) in D-dimer, fibrinogen, or protein C with weight loss. Significant (p<0.05) decreases were observed in the combined treatment groups compared with the control group for mean PAI-1 (31% decline), t-PA antigen (24% decline), and factor VII (11% decline). Decreases in these hemostatic variables were correlated with the amount of weight lost and the degree that plasma triglycerides declined; these correlations were stronger in men than women. These findings suggest that weight loss can improve abnormalities in hemostatic factors associated with obesity.

Original languageEnglish (US)
Pages (from-to)162-169
Number of pages8
JournalArteriosclerosis and Thrombosis
Volume13
Issue number2
DOIs
StatePublished - 1993

Keywords

  • coagulation
  • fibrinolysis
  • hemostasis
  • obesity
  • plasminogen activator inhibitor-1
  • tissue-type plasminogen activator

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