Impact of weight loss on ankle-brachial index and interartery blood pressures

Mark A. Espeland; Cora E. Lewis; Judy Bahnson; William C. Knowler; Judith G. Regensteiner; Sarah A. Gaussoin; Daniel Beavers; Karen C. Johnson; Frederick L. Brancati; Lee Swartz; Lawrence Cheskin; Jeanne M. Clark; Kerry Stewart; Richard Rubin; Jean Arceci; Suzanne Ball; Jeanne Charleston; Danielle Diggins; Mia Johnson; Joyce Lambert; Kathy Michalski; Dawn Jiggetts; Chanchai Sapun; George A. Bray; Kristi Rau; Allison Strate; Frank L. Greenway; Donna H. Ryan; Donald Williamson; Brandi Armand; Jennifer Arceneaux; Amy Bachand; Michelle Begnaud; Betsy Berhard; Elizabeth Caderette; Barbara Cerniauskas; David Creel; Diane Crow; Crystal Duncan; Helen Guay; Carolyn Johnson; Nancy Kora; Kelly LaFleur; Kim Landry; Missy Lingle; Jennifer Perault; Cindy Puckett; Carolyn Thorson; Richard S. Crow; Susan K. Raatz; the Look AHEAD Research Group

doi:10.1002/oby.20658

Impact of weight loss on ankle-brachial index and interartery blood pressures

Mark A. Espeland, Cora E. Lewis, Judy Bahnson, William C. Knowler, Judith G. Regensteiner, Sarah A. Gaussoin, Daniel Beavers, Karen C. Johnson, Frederick L. Brancati, Lee Swartz, Lawrence Cheskin, Jeanne M. Clark, Kerry Stewart, Richard Rubin, Jean Arceci, Suzanne Ball, Jeanne Charleston, Danielle Diggins, Mia Johnson, Joyce LambertKathy Michalski, Dawn Jiggetts, Chanchai Sapun, George A. Bray, Kristi Rau, Allison Strate, Frank L. Greenway, Donna H. Ryan, Donald Williamson, Brandi Armand, Jennifer Arceneaux, Amy Bachand, Michelle Begnaud, Betsy Berhard, Elizabeth Caderette, Barbara Cerniauskas, David Creel, Diane Crow, Crystal Duncan, Helen Guay, Carolyn Johnson, Nancy Kora, Kelly LaFleur, Kim Landry, Missy Lingle, Jennifer Perault, Cindy Puckett, Carolyn Thorson, Richard S. Crow, Susan K. Raatz, the Look AHEAD Research Group

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.

Original language	English (US)
Pages (from-to)	1032-1041
Number of pages	10
Journal	Obesity
Volume	22
Issue number	4
DOIs	https://doi.org/10.1002/oby.20658
State	Published - Apr 1 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1002/oby.20658

Find It

Find It at U of M Libraries

Cite this

Espeland, M. A., Lewis, C. E., Bahnson, J., Knowler, W. C., Regensteiner, J. G., Gaussoin, S. A., Beavers, D., Johnson, K. C., Brancati, F. L., Swartz, L., Cheskin, L., Clark, J. M., Stewart, K., Rubin, R., Arceci, J., Ball, S., Charleston, J., Diggins, D., Johnson, M., ... the Look AHEAD Research Group (2014). Impact of weight loss on ankle-brachial index and interartery blood pressures. Obesity, 22(4), 1032-1041. https://doi.org/10.1002/oby.20658

Espeland, MA, Lewis, CE, Bahnson, J, Knowler, WC, Regensteiner, JG, Gaussoin, SA, Beavers, D, Johnson, KC, Brancati, FL, Swartz, L, Cheskin, L, Clark, JM, Stewart, K, Rubin, R, Arceci, J, Ball, S, Charleston, J, Diggins, D, Johnson, M, Lambert, J, Michalski, K, Jiggetts, D, Sapun, C, Bray, GA, Rau, K, Strate, A, Greenway, FL, Ryan, DH, Williamson, D, Armand, B, Arceneaux, J, Bachand, A, Begnaud, M, Berhard, B, Caderette, E, Cerniauskas, B, Creel, D, Crow, D, Duncan, C, Guay, H, Johnson, C, Kora, N, LaFleur, K, Landry, K, Lingle, M, Perault, J, Puckett, C, Thorson, C, Crow, RS, Raatz, SK & the Look AHEAD Research Group 2014, 'Impact of weight loss on ankle-brachial index and interartery blood pressures', Obesity, vol. 22, no. 4, pp. 1032-1041. https://doi.org/10.1002/oby.20658

@article{80ec917c98df48b9b4b619fb6c8d2f96,

title = "Impact of weight loss on ankle-brachial index and interartery blood pressures",

abstract = "Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.",

author = "Espeland, {Mark A.} and Lewis, {Cora E.} and Judy Bahnson and Knowler, {William C.} and Regensteiner, {Judith G.} and Gaussoin, {Sarah A.} and Daniel Beavers and Johnson, {Karen C.} and Brancati, {Frederick L.} and Lee Swartz and Lawrence Cheskin and Clark, {Jeanne M.} and Kerry Stewart and Richard Rubin and Jean Arceci and Suzanne Ball and Jeanne Charleston and Danielle Diggins and Mia Johnson and Joyce Lambert and Kathy Michalski and Dawn Jiggetts and Chanchai Sapun and Bray, {George A.} and Kristi Rau and Allison Strate and Greenway, {Frank L.} and Ryan, {Donna H.} and Donald Williamson and Brandi Armand and Jennifer Arceneaux and Amy Bachand and Michelle Begnaud and Betsy Berhard and Elizabeth Caderette and Barbara Cerniauskas and David Creel and Diane Crow and Crystal Duncan and Helen Guay and Carolyn Johnson and Nancy Kora and Kelly LaFleur and Kim Landry and Missy Lingle and Jennifer Perault and Cindy Puckett and Carolyn Thorson and Crow, {Richard S.} and Raatz, {Susan K.} and {the Look AHEAD Research Group}",

year = "2014",

month = apr,

day = "1",

doi = "10.1002/oby.20658",

language = "English (US)",

volume = "22",

pages = "1032--1041",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Impact of weight loss on ankle-brachial index and interartery blood pressures

AU - Espeland, Mark A.

AU - Lewis, Cora E.

AU - Bahnson, Judy

AU - Knowler, William C.

AU - Regensteiner, Judith G.

AU - Gaussoin, Sarah A.

AU - Beavers, Daniel

AU - Johnson, Karen C.

AU - Brancati, Frederick L.

AU - Swartz, Lee

AU - Cheskin, Lawrence

AU - Clark, Jeanne M.

AU - Stewart, Kerry

AU - Rubin, Richard

AU - Arceci, Jean

AU - Ball, Suzanne

AU - Charleston, Jeanne

AU - Diggins, Danielle

AU - Johnson, Mia

AU - Lambert, Joyce

AU - Michalski, Kathy

AU - Jiggetts, Dawn

AU - Sapun, Chanchai

AU - Bray, George A.

AU - Rau, Kristi

AU - Strate, Allison

AU - Greenway, Frank L.

AU - Ryan, Donna H.

AU - Williamson, Donald

AU - Armand, Brandi

AU - Arceneaux, Jennifer

AU - Bachand, Amy

AU - Begnaud, Michelle

AU - Berhard, Betsy

AU - Caderette, Elizabeth

AU - Cerniauskas, Barbara

AU - Creel, David

AU - Crow, Diane

AU - Duncan, Crystal

AU - Guay, Helen

AU - Johnson, Carolyn

AU - Kora, Nancy

AU - LaFleur, Kelly

AU - Landry, Kim

AU - Lingle, Missy

AU - Perault, Jennifer

AU - Puckett, Cindy

AU - Thorson, Carolyn

AU - Crow, Richard S.

AU - Raatz, Susan K.

AU - the Look AHEAD Research Group

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.

AB - Objective To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis. Methods The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle-brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants. Results ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; P = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: P = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (P < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (P = 0.01)]. Conclusions Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.

UR - http://www.scopus.com/inward/record.url?scp=84897382538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897382538&partnerID=8YFLogxK

U2 - 10.1002/oby.20658

DO - 10.1002/oby.20658

M3 - Article

C2 - 24174392

AN - SCOPUS:84897382538

SN - 1930-7381

VL - 22

SP - 1032

EP - 1041

JO - Obesity

JF - Obesity

IS - 4

ER -

Impact of weight loss on ankle-brachial index and interartery blood pressures

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this