Impact of surgery and chemotherapy on von Willebrand factor and vascular endothelial growth factor levels in colorectal cancer

Ignacio Gil Bazo, Victoria Catalán González, Álvaro Alonso Gutiérrez, Javier Rodríguez Rodríguez, José Antonio Páramo Fernández, Juan De La Cámara Gómez, José Luis Hernández Lizoain, Jesús García Foncillas López

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Introduction. von Willebrand factor (vWf) is thought to mediate binding of tumour cells to platelets and to favour their systemic spreading capacity. Platelets involved in tumour angiogenesis are capable of releasing vascular endothelial growth factor (VEGF). Hence, levels of vWf and VEGF may correlate with cancer stage. The objectives are determine the impact of surgery and chemotherapy on vWf and VEGF in colorectal cancer (CRC) patients. Material and methods. Twenty healthy volunteers (group 1), 14 patients with locally advanced CRC (group 2) and 12 patients with metastatic CRC (group 3) were enrolled. Blood samples were taken at recruitment in group 1, and before and after surgery and chemotherapy in groups 2 and 3, respectively. Blood levels of vWf, VEGF, platelet count, C-reactive protein (CRP), cerulo-plasmin and carcinoembrionary antigen (CEA) were measured. Results. At baseline, group 3 showed higher concentrations of vWf than the other groups (p<0.05). In group 2, vWf became elevated 40% post-surgery (p=0.016), independently of changes in CRP or ce-ruloplasmin. In group 3, chemotherapy caused a 42% reduction in VEGF (p=0.015). Conclusions. There was a strong correlation between higher vWf levels and more advanced CRC stage at diagnosis. These levels were elevated post-surgery in patients with locally advanced CRC. Chemotherapy significantly decreased VEGF in metastatic CRC patients before CEA showed any significant change.

Original languageEnglish (US)
Pages (from-to)150-155
Number of pages6
JournalClinical and Translational Oncology
Volume7
Issue number4
DOIs
StatePublished - May 1 2005

Keywords

  • Angiogenesis
  • Colorectal cancer
  • VEGF
  • VWf

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