Abstract
To determine whether defects in mucosal immunity were associated with invasive disease caused by a mucosal pathogen, Streptococcus pneumoniae, levels of salivary immunoglobulins and nonspecific immune factors were compared in subjects with human immunodeficiency virus type 1 (HIV-1) infection and in HIV-1-seronegative subjects with and without pneumococcal bacteremia. The IgA2 subclass may be of particular importance because S. pneumoniae produces IgA1 protease, which cleaves IgA1 but not IgA2. Levels (37-56 μg/mL) and proportions (11%-17%) of IgA2 were similar among groups. Serotype-specific capsular salivary 19A was present in a minority of patients with acute bacteremia. Levels of lactoferrin were increased with bacteremia. Neither selective mucosal IgA2 deficiency nor impaired nonspecific upper respiratory mucosal responses were associated with invasive pneumococcal disease during HIV-1 infection; thus, other defects in mucosal cellular responses and systemic immunity may predispose HIV-1-infected patients to invasive pneumococcal disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 566-570 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 172 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1995 |
Bibliographical note
Funding Information:Received 23 January 1995; revised 30 March 1995. Presented in part: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Florida, 4 October 1994. Written informed consent was obtained from each subject for protocols approved by the University of California at San Francisco and San Francisco General Hospital and the Minneapolis VA Medical Center. Financial support: National Institutes of Health (AI-31373, DE-42600), Department ofVeterans Affairs Research Service, and Minnesota Medical Foundation. Reprints or correspondence: Dr. Edward N. Janoff, VA Medical Center, Infectious Disease Section (151), One Veterans Dr., Minneapolis, MN 55417.
