Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma

Ran C Zhang; Nujsaubnusi C Vue; Lisa U Obasi; Rachel I Vogel; Amar T Subramanian; Mahmoud A Khalifa; Buvana R Reddy; Britt K Erickson

doi:10.1097/lgt.0000000000000618

Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma

Ran C Zhang, Nujsaubnusi C Vue, Lisa U Obasi, Rachel I Vogel, Amar T Subramanian, Mahmoud A Khalifa, Buvana R Reddy, Britt K Erickson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

OBJECTIVE: The aim of the study was to determine the impact of screening modality on the detection of cervical adenocarcinoma in situ (AIS) and adenocarcinoma.

MATERIALS AND METHODS: This was a cross-sectional study of patients with AIS or adenocarcinoma who had undergone routine screening with cytology and high-risk human papillomavirus (HPV) cotesting between January 2007 and December 2017. Patients were stratified into 3 groups by screening test results: (1) HPV positive with abnormal cytology (HPV+/Pap+), (2) HPV negative with abnormal cytology (HPV-/Pap+), and (3) HPV positive with normal cytology (HPV+/Pap-). Demographic and clinical characteristics were collected. Data were analyzed with χ2, Fisher exact tests, and t tests as appropriate.

RESULTS: Of the 118 patients diagnosed with AIS (n = 97) or adenocarcinoma (n = 21) after abnormal screening tests, 92 (78%) were detected by HPV+/Pap+, 15 (12.7%) were HPV+/Pap-, and 11 (9.3%) were HPV-/Pap+. Demographics were similar between groups, although the HPV+/Pap- patients had higher body mass indices. Rates of definitive hysterectomy were similar between groups (53.3%-80.0%, p = .11).

CONCLUSIONS: In our cohort, a significant proportion of AIS and adenocarcinoma was detected by both HPV alone (with normal cytology) and cytology alone (with negative HPV), suggesting that cotesting with both HPV and cytology may be a more sensitive method of detection of AIS and adenocarcinoma.

Original language	English (US)
Pages (from-to)	267-269
Number of pages	3
Journal	Journal of lower genital tract disease
Volume	25
Issue number	4
DOIs	https://doi.org/10.1097/lgt.0000000000000618
State	Published - Oct 1 2021

Bibliographical note

Funding Information:
Research reported in this publication was supported to B.K.E. by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Award Number K12HD055887. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The other authors have declared they have no conflicts of interest.

Publisher Copyright:
© Lippincott Williams Wilkins.

Keywords

Pap test
cervical cancer
cervical cancer screening
cold knife cone
cotesting
cytology test
human papillomavirus
loop electrosurgical excision procedure

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Journal Article

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10.1097/lgt.0000000000000618

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title = "Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma",

abstract = "OBJECTIVE: The aim of the study was to determine the impact of screening modality on the detection of cervical adenocarcinoma in situ (AIS) and adenocarcinoma.MATERIALS AND METHODS: This was a cross-sectional study of patients with AIS or adenocarcinoma who had undergone routine screening with cytology and high-risk human papillomavirus (HPV) cotesting between January 2007 and December 2017. Patients were stratified into 3 groups by screening test results: (1) HPV positive with abnormal cytology (HPV+/Pap+), (2) HPV negative with abnormal cytology (HPV-/Pap+), and (3) HPV positive with normal cytology (HPV+/Pap-). Demographic and clinical characteristics were collected. Data were analyzed with χ2, Fisher exact tests, and t tests as appropriate.RESULTS: Of the 118 patients diagnosed with AIS (n = 97) or adenocarcinoma (n = 21) after abnormal screening tests, 92 (78%) were detected by HPV+/Pap+, 15 (12.7%) were HPV+/Pap-, and 11 (9.3%) were HPV-/Pap+. Demographics were similar between groups, although the HPV+/Pap- patients had higher body mass indices. Rates of definitive hysterectomy were similar between groups (53.3%-80.0%, p = .11).CONCLUSIONS: In our cohort, a significant proportion of AIS and adenocarcinoma was detected by both HPV alone (with normal cytology) and cytology alone (with negative HPV), suggesting that cotesting with both HPV and cytology may be a more sensitive method of detection of AIS and adenocarcinoma.",

keywords = "Pap test, cervical cancer, cervical cancer screening, cold knife cone, cotesting, cytology test, human papillomavirus, loop electrosurgical excision procedure",

author = "Zhang, {Ran C} and Vue, {Nujsaubnusi C} and Obasi, {Lisa U} and Vogel, {Rachel I} and Subramanian, {Amar T} and Khalifa, {Mahmoud A} and Reddy, {Buvana R} and Erickson, {Britt K}",

note = "Funding Information: Research reported in this publication was supported to B.K.E. by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Award Number K12HD055887. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The other authors have declared they have no conflicts of interest. Publisher Copyright: {\textcopyright} Lippincott Williams Wilkins.",

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doi = "10.1097/lgt.0000000000000618",

language = "English (US)",

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T1 - Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma

AU - Zhang, Ran C

AU - Vue, Nujsaubnusi C

AU - Obasi, Lisa U

AU - Vogel, Rachel I

AU - Subramanian, Amar T

AU - Khalifa, Mahmoud A

AU - Reddy, Buvana R

AU - Erickson, Britt K

N1 - Funding Information: Research reported in this publication was supported to B.K.E. by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Award Number K12HD055887. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The other authors have declared they have no conflicts of interest. Publisher Copyright: © Lippincott Williams Wilkins.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - OBJECTIVE: The aim of the study was to determine the impact of screening modality on the detection of cervical adenocarcinoma in situ (AIS) and adenocarcinoma.MATERIALS AND METHODS: This was a cross-sectional study of patients with AIS or adenocarcinoma who had undergone routine screening with cytology and high-risk human papillomavirus (HPV) cotesting between January 2007 and December 2017. Patients were stratified into 3 groups by screening test results: (1) HPV positive with abnormal cytology (HPV+/Pap+), (2) HPV negative with abnormal cytology (HPV-/Pap+), and (3) HPV positive with normal cytology (HPV+/Pap-). Demographic and clinical characteristics were collected. Data were analyzed with χ2, Fisher exact tests, and t tests as appropriate.RESULTS: Of the 118 patients diagnosed with AIS (n = 97) or adenocarcinoma (n = 21) after abnormal screening tests, 92 (78%) were detected by HPV+/Pap+, 15 (12.7%) were HPV+/Pap-, and 11 (9.3%) were HPV-/Pap+. Demographics were similar between groups, although the HPV+/Pap- patients had higher body mass indices. Rates of definitive hysterectomy were similar between groups (53.3%-80.0%, p = .11).CONCLUSIONS: In our cohort, a significant proportion of AIS and adenocarcinoma was detected by both HPV alone (with normal cytology) and cytology alone (with negative HPV), suggesting that cotesting with both HPV and cytology may be a more sensitive method of detection of AIS and adenocarcinoma.

AB - OBJECTIVE: The aim of the study was to determine the impact of screening modality on the detection of cervical adenocarcinoma in situ (AIS) and adenocarcinoma.MATERIALS AND METHODS: This was a cross-sectional study of patients with AIS or adenocarcinoma who had undergone routine screening with cytology and high-risk human papillomavirus (HPV) cotesting between January 2007 and December 2017. Patients were stratified into 3 groups by screening test results: (1) HPV positive with abnormal cytology (HPV+/Pap+), (2) HPV negative with abnormal cytology (HPV-/Pap+), and (3) HPV positive with normal cytology (HPV+/Pap-). Demographic and clinical characteristics were collected. Data were analyzed with χ2, Fisher exact tests, and t tests as appropriate.RESULTS: Of the 118 patients diagnosed with AIS (n = 97) or adenocarcinoma (n = 21) after abnormal screening tests, 92 (78%) were detected by HPV+/Pap+, 15 (12.7%) were HPV+/Pap-, and 11 (9.3%) were HPV-/Pap+. Demographics were similar between groups, although the HPV+/Pap- patients had higher body mass indices. Rates of definitive hysterectomy were similar between groups (53.3%-80.0%, p = .11).CONCLUSIONS: In our cohort, a significant proportion of AIS and adenocarcinoma was detected by both HPV alone (with normal cytology) and cytology alone (with negative HPV), suggesting that cotesting with both HPV and cytology may be a more sensitive method of detection of AIS and adenocarcinoma.

KW - Pap test

KW - cervical cancer

KW - cervical cancer screening

KW - cold knife cone

KW - cotesting

KW - cytology test

KW - human papillomavirus

KW - loop electrosurgical excision procedure

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Impact of Screening Modality on the Detection of Cervical Adenocarcinoma In Situ and Adenocarcinoma

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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