Impact of Pretransplantation 18F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma

Veronika Bachanova; Linda J. Burns; Kwang Woo Ahn; Ginna G. Laport; Görgün Akpek; Mohamed A. Kharfan-Dabaja; Taiga Nishihori; Edward Agura; Philippe Armand; Samantha M. Jaglowski; Mitchell S. Cairo; Amanda F. Cashen; Jonathon B. Cohen; Anita D'Souza; César O. Freytes; Robert Peter Gale; Siddhartha Ganguly; Nilanjan Ghosh; Leona A. Holmberg; David J. Inwards; Abraham S. Kanate; Hillard M. Lazarus; Adriana K. Malone; Reinhold Munker; Alberto Mussetti; Maxim Norkin; Tim D. Prestidge; Jacob M. Rowe; Prakash Satwani; Tanya Siddiqi; Patrick J. Stiff; Basem M. William; Baldeep Wirk; David G. Maloney; Sonali M. Smith; Anna M. Sureda; Jeanette Carreras; Mehdi Hamadani

doi:10.1016/j.bbmt.2015.05.007

Impact of Pretransplantation ¹⁸F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma

Veronika Bachanova, Linda J. Burns, Kwang Woo Ahn, Ginna G. Laport, Görgün Akpek, Mohamed A. Kharfan-Dabaja, Taiga Nishihori, Edward Agura, Philippe Armand, Samantha M. Jaglowski, Mitchell S. Cairo, Amanda F. Cashen, Jonathon B. Cohen, Anita D'Souza, César O. Freytes, Robert Peter Gale, Siddhartha Ganguly, Nilanjan Ghosh, Leona A. Holmberg, David J. InwardsAbraham S. Kanate, Hillard M. Lazarus, Adriana K. Malone, Reinhold Munker, Alberto Mussetti, Maxim Norkin, Tim D. Prestidge, Jacob M. Rowe, Prakash Satwani, Tanya Siddiqi, Patrick J. Stiff, Basem M. William, Baldeep Wirk, David G. Maloney, Sonali M. Smith, Anna M. Sureda, Jeanette Carreras, Mehdi Hamadani

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Assessment with ¹⁸F-fluorodeoxy glucose (FDG)-positron emission tomography (PET) before hematopoietic cell transplantation (HCT) for lymphoma may be prognostic for outcomes. Patients with chemotherapy-sensitive non-Hodgkin lymphoma (NHL) undergoing allogeneic HCT reported to the Center of International Blood and Marrow Transplantation Registry between 2007 and 2012 were included. Pre-HCT PET status (positive versus negative) was determined by the reporting transplantation centers. We analyzed 336 patients; median age was 55 years and 60% were males. Follicular lymphoma (n = 104) was more common than large cell (n = 85), mantle cell (n = 69), and mature natural killer or T cell lymphoma (n = 78); two thirds of the cohort received reduced-intensity conditioning; one half had unrelated donor grafts. Patients underwent PET scanning a median of 1 month (range, .07 to 2.83 months) before HCT; 159 were PET positive and 177 were PET negative. At 3 years, relapse/progression, progression-free survival (PFS), and overall survival (OS) in PET-positive versus PET-negative groups were 40% versus 26%; P = .007; 43% versus 47%; P = .47; and 58% versus 60%; P = .73, respectively. On multivariate analysis, a positive pretransplantation PET was associated with an increased risk of relapse/progression (risk ratio [RR], 1.86; P = .001) but was not associated with increased mortality (RR, 1.29, 95% confidence interval [CI], .96 to 1.7; P = .08), therapy failure (RR, 1.32; 95% CI, .95 to 1.84; P = .10), or nonrelapse mortality (RR, .75; 95% CI, .48 to 1.18; P = .22). PET status conferred no influence on graft-versus-host disease. A positive PET scan before HCT is associated with increased relapse risk but should not be interpreted as a barrier to a successful allograft. PET status does not appear to predict survival after allogeneic HCT for NHL.

Original language	English (US)
Pages (from-to)	1605-1611
Number of pages	7
Journal	Biology of Blood and Marrow Transplantation
Volume	21
Issue number	9
DOIs	https://doi.org/10.1016/j.bbmt.2015.05.007
State	Published - Sep 1 2015

Bibliographical note

Funding Information:
The CIBMTR is supported by Public Health Service grant/cooperative agreement [ U24-CA076518 ] from the National Cancer Institute , the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases ; a grant/cooperative agreement [ 5U10HL069294 ] from National Heart, Lung, and Blood Institute and National Cancer Institute ; a contract [HHSH250201200016C] with Health Resources and Services Administration; 2 grants [ N00014-12-1-0142 ] and [ N00014-13-1-0039 ] from the Office of Naval Research ; and grants from * Actinium Pharmaceuticals ; Allos Therapeutics, Inc. ; * Amgen ; anonymous donation to the Medical College of Wisconsin ; Ariad ; Be The Match Foundation ; * Blue Cross and Blue Shield Association ; * Celgene Corporation ; Chimerix, Inc. ; Fred Hutchinson Cancer Research Center ; Fresenius-Biotech North America, Inc. ; * Gamida Cell Teva Joint Venture Ltd. ; Genentech, Inc. ; * Gentium SpA ; Genzyme Corporation ; GlaxoSmithKline ; Health Research, Inc. ; Roswell Park Cancer Institute ; HistoGenetics ; Incyte Corporation ; Jeff Gordon Children's Foundation ; Kiadis Pharma ; The Leukemia & Lymphoma Society ; Medac GmbH ; The Medical College of Wisconsin ; Merck & Co., Inc. ; Millennium: The Takeda Oncology Co. ; * Milliman USA, Inc. ; * Miltenyi Biotec ; National Marrow Donor Program ; Onyx Pharmaceuticals ; Optum Healthcare Solutions, Inc. ; Osiris Therapeutics ; Otsuka America Pharmaceutical, Inc. ; Perkin Elmer, Inc. ; * Remedy Informatics ; * Sanofi US ; Seattle Genetics ; Sigma-Tau Pharmaceuticals ; Soligenix, Inc. ; St. Baldrick's Foundation ; StemCyte, A Global Cord Blood Therapeutics Co. ; Stemsoft Software, Inc. ; Swedish Orphan Biovitrum ; * Tarix Pharmaceuticals ; * Terumo BCT ; * Teva Neuroscience, Inc. ; * Therakos ; University of Minnesota ; University of Utah ; and * WellPoint . The views expressed in this article do not reflect the official policy or position of the National Institute of Health, the Department of the Navy, the Department of Defense, Health Resources and Services Administration or any other agency of the US Government.

Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.

Keywords

Allogeneic transplantation
Non-Hodgkin lymphoma
Positron emission tomography

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10.1016/j.bbmt.2015.05.007

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Bachanova, V., Burns, L. J., Ahn, K. W., Laport, G. G., Akpek, G., Kharfan-Dabaja, M. A., Nishihori, T., Agura, E., Armand, P., Jaglowski, S. M., Cairo, M. S., Cashen, A. F., Cohen, J. B., D'Souza, A., Freytes, C. O., Gale, R. P., Ganguly, S., Ghosh, N., Holmberg, L. A., ... Hamadani, M. (2015). Impact of Pretransplantation ¹⁸F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma. Biology of Blood and Marrow Transplantation, 21(9), 1605-1611. https://doi.org/10.1016/j.bbmt.2015.05.007

Impact of Pretransplantation ¹⁸F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma. / Bachanova, Veronika; Burns, Linda J.; Ahn, Kwang Woo et al.

In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 9, 01.09.2015, p. 1605-1611.

Research output: Contribution to journal › Article › peer-review

Bachanova, V, Burns, LJ, Ahn, KW, Laport, GG, Akpek, G, Kharfan-Dabaja, MA, Nishihori, T, Agura, E, Armand, P, Jaglowski, SM, Cairo, MS, Cashen, AF, Cohen, JB, D'Souza, A, Freytes, CO, Gale, RP, Ganguly, S, Ghosh, N, Holmberg, LA, Inwards, DJ, Kanate, AS, Lazarus, HM, Malone, AK, Munker, R, Mussetti, A, Norkin, M, Prestidge, TD, Rowe, JM, Satwani, P, Siddiqi, T, Stiff, PJ, William, BM, Wirk, B, Maloney, DG, Smith, SM, Sureda, AM, Carreras, J & Hamadani, M 2015, 'Impact of Pretransplantation ¹⁸F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma', Biology of Blood and Marrow Transplantation, vol. 21, no. 9, pp. 1605-1611. https://doi.org/10.1016/j.bbmt.2015.05.007

@article{01b969a012d24c3496dc70e6d5378e57,

title = "Impact of Pretransplantation 18F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma",

abstract = "Assessment with 18F-fluorodeoxy glucose (FDG)-positron emission tomography (PET) before hematopoietic cell transplantation (HCT) for lymphoma may be prognostic for outcomes. Patients with chemotherapy-sensitive non-Hodgkin lymphoma (NHL) undergoing allogeneic HCT reported to the Center of International Blood and Marrow Transplantation Registry between 2007 and 2012 were included. Pre-HCT PET status (positive versus negative) was determined by the reporting transplantation centers. We analyzed 336 patients; median age was 55 years and 60% were males. Follicular lymphoma (n = 104) was more common than large cell (n = 85), mantle cell (n = 69), and mature natural killer or T cell lymphoma (n = 78); two thirds of the cohort received reduced-intensity conditioning; one half had unrelated donor grafts. Patients underwent PET scanning a median of 1 month (range, .07 to 2.83 months) before HCT; 159 were PET positive and 177 were PET negative. At 3 years, relapse/progression, progression-free survival (PFS), and overall survival (OS) in PET-positive versus PET-negative groups were 40% versus 26%; P = .007; 43% versus 47%; P = .47; and 58% versus 60%; P = .73, respectively. On multivariate analysis, a positive pretransplantation PET was associated with an increased risk of relapse/progression (risk ratio [RR], 1.86; P = .001) but was not associated with increased mortality (RR, 1.29, 95% confidence interval [CI], .96 to 1.7; P = .08), therapy failure (RR, 1.32; 95% CI, .95 to 1.84; P = .10), or nonrelapse mortality (RR, .75; 95% CI, .48 to 1.18; P = .22). PET status conferred no influence on graft-versus-host disease. A positive PET scan before HCT is associated with increased relapse risk but should not be interpreted as a barrier to a successful allograft. PET status does not appear to predict survival after allogeneic HCT for NHL.",

keywords = "Allogeneic transplantation, Non-Hodgkin lymphoma, Positron emission tomography",

author = "Veronika Bachanova and Burns, {Linda J.} and Ahn, {Kwang Woo} and Laport, {Ginna G.} and G{\"o}rg{\"u}n Akpek and Kharfan-Dabaja, {Mohamed A.} and Taiga Nishihori and Edward Agura and Philippe Armand and Jaglowski, {Samantha M.} and Cairo, {Mitchell S.} and Cashen, {Amanda F.} and Cohen, {Jonathon B.} and Anita D'Souza and Freytes, {C{\'e}sar O.} and Gale, {Robert Peter} and Siddhartha Ganguly and Nilanjan Ghosh and Holmberg, {Leona A.} and Inwards, {David J.} and Kanate, {Abraham S.} and Lazarus, {Hillard M.} and Malone, {Adriana K.} and Reinhold Munker and Alberto Mussetti and Maxim Norkin and Prestidge, {Tim D.} and Rowe, {Jacob M.} and Prakash Satwani and Tanya Siddiqi and Stiff, {Patrick J.} and William, {Basem M.} and Baldeep Wirk and Maloney, {David G.} and Smith, {Sonali M.} and Sureda, {Anna M.} and Jeanette Carreras and Mehdi Hamadani",

note = "Funding Information: The CIBMTR is supported by Public Health Service grant/cooperative agreement [ U24-CA076518 ] from the National Cancer Institute , the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases ; a grant/cooperative agreement [ 5U10HL069294 ] from National Heart, Lung, and Blood Institute and National Cancer Institute ; a contract [HHSH250201200016C] with Health Resources and Services Administration; 2 grants [ N00014-12-1-0142 ] and [ N00014-13-1-0039 ] from the Office of Naval Research ; and grants from * Actinium Pharmaceuticals ; Allos Therapeutics, Inc. ; * Amgen ; anonymous donation to the Medical College of Wisconsin ; Ariad ; Be The Match Foundation ; * Blue Cross and Blue Shield Association ; * Celgene Corporation ; Chimerix, Inc. ; Fred Hutchinson Cancer Research Center ; Fresenius-Biotech North America, Inc. ; * Gamida Cell Teva Joint Venture Ltd. ; Genentech, Inc. ; * Gentium SpA ; Genzyme Corporation ; GlaxoSmithKline ; Health Research, Inc. ; Roswell Park Cancer Institute ; HistoGenetics ; Incyte Corporation ; Jeff Gordon Children's Foundation ; Kiadis Pharma ; The Leukemia & Lymphoma Society ; Medac GmbH ; The Medical College of Wisconsin ; Merck & Co., Inc. ; Millennium: The Takeda Oncology Co. ; * Milliman USA, Inc. ; * Miltenyi Biotec ; National Marrow Donor Program ; Onyx Pharmaceuticals ; Optum Healthcare Solutions, Inc. ; Osiris Therapeutics ; Otsuka America Pharmaceutical, Inc. ; Perkin Elmer, Inc. ; * Remedy Informatics ; * Sanofi US ; Seattle Genetics ; Sigma-Tau Pharmaceuticals ; Soligenix, Inc. ; St. Baldrick's Foundation ; StemCyte, A Global Cord Blood Therapeutics Co. ; Stemsoft Software, Inc. ; Swedish Orphan Biovitrum ; * Tarix Pharmaceuticals ; * Terumo BCT ; * Teva Neuroscience, Inc. ; * Therakos ; University of Minnesota ; University of Utah ; and * WellPoint . The views expressed in this article do not reflect the official policy or position of the National Institute of Health, the Department of the Navy, the Department of Defense, Health Resources and Services Administration or any other agency of the US Government. Publisher Copyright: {\textcopyright} 2015 American Society for Blood and Marrow Transplantation.",

year = "2015",

month = sep,

day = "1",

doi = "10.1016/j.bbmt.2015.05.007",

language = "English (US)",

volume = "21",

pages = "1605--1611",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - Impact of Pretransplantation 18F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma

AU - Bachanova, Veronika

AU - Burns, Linda J.

AU - Ahn, Kwang Woo

AU - Laport, Ginna G.

AU - Akpek, Görgün

AU - Kharfan-Dabaja, Mohamed A.

AU - Nishihori, Taiga

AU - Agura, Edward

AU - Armand, Philippe

AU - Jaglowski, Samantha M.

AU - Cairo, Mitchell S.

AU - Cashen, Amanda F.

AU - Cohen, Jonathon B.

AU - D'Souza, Anita

AU - Freytes, César O.

AU - Gale, Robert Peter

AU - Ganguly, Siddhartha

AU - Ghosh, Nilanjan

AU - Holmberg, Leona A.

AU - Inwards, David J.

AU - Kanate, Abraham S.

AU - Lazarus, Hillard M.

AU - Malone, Adriana K.

AU - Munker, Reinhold

AU - Mussetti, Alberto

AU - Norkin, Maxim

AU - Prestidge, Tim D.

AU - Rowe, Jacob M.

AU - Satwani, Prakash

AU - Siddiqi, Tanya

AU - Stiff, Patrick J.

AU - William, Basem M.

AU - Wirk, Baldeep

AU - Maloney, David G.

AU - Smith, Sonali M.

AU - Sureda, Anna M.

AU - Carreras, Jeanette

AU - Hamadani, Mehdi

N1 - Funding Information: The CIBMTR is supported by Public Health Service grant/cooperative agreement [ U24-CA076518 ] from the National Cancer Institute , the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases ; a grant/cooperative agreement [ 5U10HL069294 ] from National Heart, Lung, and Blood Institute and National Cancer Institute ; a contract [HHSH250201200016C] with Health Resources and Services Administration; 2 grants [ N00014-12-1-0142 ] and [ N00014-13-1-0039 ] from the Office of Naval Research ; and grants from * Actinium Pharmaceuticals ; Allos Therapeutics, Inc. ; * Amgen ; anonymous donation to the Medical College of Wisconsin ; Ariad ; Be The Match Foundation ; * Blue Cross and Blue Shield Association ; * Celgene Corporation ; Chimerix, Inc. ; Fred Hutchinson Cancer Research Center ; Fresenius-Biotech North America, Inc. ; * Gamida Cell Teva Joint Venture Ltd. ; Genentech, Inc. ; * Gentium SpA ; Genzyme Corporation ; GlaxoSmithKline ; Health Research, Inc. ; Roswell Park Cancer Institute ; HistoGenetics ; Incyte Corporation ; Jeff Gordon Children's Foundation ; Kiadis Pharma ; The Leukemia & Lymphoma Society ; Medac GmbH ; The Medical College of Wisconsin ; Merck & Co., Inc. ; Millennium: The Takeda Oncology Co. ; * Milliman USA, Inc. ; * Miltenyi Biotec ; National Marrow Donor Program ; Onyx Pharmaceuticals ; Optum Healthcare Solutions, Inc. ; Osiris Therapeutics ; Otsuka America Pharmaceutical, Inc. ; Perkin Elmer, Inc. ; * Remedy Informatics ; * Sanofi US ; Seattle Genetics ; Sigma-Tau Pharmaceuticals ; Soligenix, Inc. ; St. Baldrick's Foundation ; StemCyte, A Global Cord Blood Therapeutics Co. ; Stemsoft Software, Inc. ; Swedish Orphan Biovitrum ; * Tarix Pharmaceuticals ; * Terumo BCT ; * Teva Neuroscience, Inc. ; * Therakos ; University of Minnesota ; University of Utah ; and * WellPoint . The views expressed in this article do not reflect the official policy or position of the National Institute of Health, the Department of the Navy, the Department of Defense, Health Resources and Services Administration or any other agency of the US Government. Publisher Copyright: © 2015 American Society for Blood and Marrow Transplantation.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Assessment with 18F-fluorodeoxy glucose (FDG)-positron emission tomography (PET) before hematopoietic cell transplantation (HCT) for lymphoma may be prognostic for outcomes. Patients with chemotherapy-sensitive non-Hodgkin lymphoma (NHL) undergoing allogeneic HCT reported to the Center of International Blood and Marrow Transplantation Registry between 2007 and 2012 were included. Pre-HCT PET status (positive versus negative) was determined by the reporting transplantation centers. We analyzed 336 patients; median age was 55 years and 60% were males. Follicular lymphoma (n = 104) was more common than large cell (n = 85), mantle cell (n = 69), and mature natural killer or T cell lymphoma (n = 78); two thirds of the cohort received reduced-intensity conditioning; one half had unrelated donor grafts. Patients underwent PET scanning a median of 1 month (range, .07 to 2.83 months) before HCT; 159 were PET positive and 177 were PET negative. At 3 years, relapse/progression, progression-free survival (PFS), and overall survival (OS) in PET-positive versus PET-negative groups were 40% versus 26%; P = .007; 43% versus 47%; P = .47; and 58% versus 60%; P = .73, respectively. On multivariate analysis, a positive pretransplantation PET was associated with an increased risk of relapse/progression (risk ratio [RR], 1.86; P = .001) but was not associated with increased mortality (RR, 1.29, 95% confidence interval [CI], .96 to 1.7; P = .08), therapy failure (RR, 1.32; 95% CI, .95 to 1.84; P = .10), or nonrelapse mortality (RR, .75; 95% CI, .48 to 1.18; P = .22). PET status conferred no influence on graft-versus-host disease. A positive PET scan before HCT is associated with increased relapse risk but should not be interpreted as a barrier to a successful allograft. PET status does not appear to predict survival after allogeneic HCT for NHL.

AB - Assessment with 18F-fluorodeoxy glucose (FDG)-positron emission tomography (PET) before hematopoietic cell transplantation (HCT) for lymphoma may be prognostic for outcomes. Patients with chemotherapy-sensitive non-Hodgkin lymphoma (NHL) undergoing allogeneic HCT reported to the Center of International Blood and Marrow Transplantation Registry between 2007 and 2012 were included. Pre-HCT PET status (positive versus negative) was determined by the reporting transplantation centers. We analyzed 336 patients; median age was 55 years and 60% were males. Follicular lymphoma (n = 104) was more common than large cell (n = 85), mantle cell (n = 69), and mature natural killer or T cell lymphoma (n = 78); two thirds of the cohort received reduced-intensity conditioning; one half had unrelated donor grafts. Patients underwent PET scanning a median of 1 month (range, .07 to 2.83 months) before HCT; 159 were PET positive and 177 were PET negative. At 3 years, relapse/progression, progression-free survival (PFS), and overall survival (OS) in PET-positive versus PET-negative groups were 40% versus 26%; P = .007; 43% versus 47%; P = .47; and 58% versus 60%; P = .73, respectively. On multivariate analysis, a positive pretransplantation PET was associated with an increased risk of relapse/progression (risk ratio [RR], 1.86; P = .001) but was not associated with increased mortality (RR, 1.29, 95% confidence interval [CI], .96 to 1.7; P = .08), therapy failure (RR, 1.32; 95% CI, .95 to 1.84; P = .10), or nonrelapse mortality (RR, .75; 95% CI, .48 to 1.18; P = .22). PET status conferred no influence on graft-versus-host disease. A positive PET scan before HCT is associated with increased relapse risk but should not be interpreted as a barrier to a successful allograft. PET status does not appear to predict survival after allogeneic HCT for NHL.

KW - Allogeneic transplantation

KW - Non-Hodgkin lymphoma

KW - Positron emission tomography

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