Impact of oral contraceptive pill use on premenstrual mood: Predictors of improvement and deterioration

Hadine Joffe, Lee S. Cohen, Bernard L. Harlow

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


OBJECTIVES: The purpose of this study was to estimate risk factors for the deterioration and improvement of premenstrual mood disturbance with oral contraceptive pill use. STUDY DESIGN: Predictors of the deleterious and beneficial effects of oral contraceptive pill use on premenstrual mood were analyzed with the use of logistic regression in a nested case-control study within a community-based cohort of 976 premenopausal women in Massachusetts. RESULTS: Of 658 women who were using oral contraceptive pills, 16.3% of the women reported oral contraceptive pill-related premenstrual mood deterioration, and 12.3% of the women reported premenstrual mood improvement. In adjusted models, previous depression was the only significant predictor of mood deterioration (odds ratio, 2.0; 95% CI, 1.1-3.8); early-onset premenstrual mood disturbance and dysmenorrhea were significant predictors of oral contraceptive pill-related mood improvement (odds ratio, 3.1 [95% CI, 1.9-5.2] and odds ratio, 2.3 [95% CI, 1.4-3.9], respectively). CONCLUSION: Oral contraceptive pills do not influence premenstrual mood in most women. Premenstrual mood is most likely to deteriorate in women with a history of depression and to improve in women with early-onset premenstrual mood disturbance or dysmenorrhea.

Original languageEnglish (US)
Pages (from-to)1523-1530
Number of pages8
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - Dec 2003


  • Depression
  • Oral contraceptive pill
  • Premenstrual mood syndrome


Dive into the research topics of 'Impact of oral contraceptive pill use on premenstrual mood: Predictors of improvement and deterioration'. Together they form a unique fingerprint.

Cite this