Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Aliye Uc, M. Bridget Zimmerman, Michael Wilschanski, Steven L. Werlin, David Troendle, Uzma Shah, Sarah J Schwarzenberg, Sue Rhee, John F. Pohl, Emily R. Perito, Joseph J. Palermo, Chee Y. Ooi, Quin Liu, Tom K. Lin, Veronique D. Morinville, Brian A. McFerron, Sohail Z. Husain, Ryan Himes, Melvin B. Heyman, Tanja Gonska & 8 others Matthew J. Giefer, Cheryl E. Gariepy, Steven D. Freedman, Douglas S. Fishman, Melena D Bellin, Bradley Barth, Maisam Abu-El-Haija, Mark E. Lowe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

Original languageEnglish (US)
Pages (from-to)967-973
Number of pages7
JournalPancreas
Volume47
Issue number8
DOIs
StatePublished - Sep 1 2018

Fingerprint

Pediatric Obesity
Chronic Pancreatitis
Pancreatitis
Body Mass Index
Thinness
Weights and Measures
Pediatrics
Exocrine Pancreatic Insufficiency
Pancreatectomy
Autologous Transplantation
Hypertriglyceridemia
Centers for Disease Control and Prevention (U.S.)
Obesity
Inflammation

Keywords

  • body mass index
  • children
  • pancreatitis

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Uc, A., Zimmerman, M. B., Wilschanski, M., Werlin, S. L., Troendle, D., Shah, U., ... Lowe, M. E. (2018). Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas, 47(8), 967-973. https://doi.org/10.1097/MPA.0000000000001120

Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. / Uc, Aliye; Zimmerman, M. Bridget; Wilschanski, Michael; Werlin, Steven L.; Troendle, David; Shah, Uzma; Schwarzenberg, Sarah J; Rhee, Sue; Pohl, John F.; Perito, Emily R.; Palermo, Joseph J.; Ooi, Chee Y.; Liu, Quin; Lin, Tom K.; Morinville, Veronique D.; McFerron, Brian A.; Husain, Sohail Z.; Himes, Ryan; Heyman, Melvin B.; Gonska, Tanja; Giefer, Matthew J.; Gariepy, Cheryl E.; Freedman, Steven D.; Fishman, Douglas S.; Bellin, Melena D; Barth, Bradley; Abu-El-Haija, Maisam; Lowe, Mark E.

In: Pancreas, Vol. 47, No. 8, 01.09.2018, p. 967-973.

Research output: Contribution to journalArticle

Uc, A, Zimmerman, MB, Wilschanski, M, Werlin, SL, Troendle, D, Shah, U, Schwarzenberg, SJ, Rhee, S, Pohl, JF, Perito, ER, Palermo, JJ, Ooi, CY, Liu, Q, Lin, TK, Morinville, VD, McFerron, BA, Husain, SZ, Himes, R, Heyman, MB, Gonska, T, Giefer, MJ, Gariepy, CE, Freedman, SD, Fishman, DS, Bellin, MD, Barth, B, Abu-El-Haija, M & Lowe, ME 2018, 'Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis', Pancreas, vol. 47, no. 8, pp. 967-973. https://doi.org/10.1097/MPA.0000000000001120
Uc A, Zimmerman MB, Wilschanski M, Werlin SL, Troendle D, Shah U et al. Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas. 2018 Sep 1;47(8):967-973. https://doi.org/10.1097/MPA.0000000000001120
Uc, Aliye ; Zimmerman, M. Bridget ; Wilschanski, Michael ; Werlin, Steven L. ; Troendle, David ; Shah, Uzma ; Schwarzenberg, Sarah J ; Rhee, Sue ; Pohl, John F. ; Perito, Emily R. ; Palermo, Joseph J. ; Ooi, Chee Y. ; Liu, Quin ; Lin, Tom K. ; Morinville, Veronique D. ; McFerron, Brian A. ; Husain, Sohail Z. ; Himes, Ryan ; Heyman, Melvin B. ; Gonska, Tanja ; Giefer, Matthew J. ; Gariepy, Cheryl E. ; Freedman, Steven D. ; Fishman, Douglas S. ; Bellin, Melena D ; Barth, Bradley ; Abu-El-Haija, Maisam ; Lowe, Mark E. / Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. In: Pancreas. 2018 ; Vol. 47, No. 8. pp. 967-973.
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abstract = "Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.",
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T1 - Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

AU - Uc, Aliye

AU - Zimmerman, M. Bridget

AU - Wilschanski, Michael

AU - Werlin, Steven L.

AU - Troendle, David

AU - Shah, Uzma

AU - Schwarzenberg, Sarah J

AU - Rhee, Sue

AU - Pohl, John F.

AU - Perito, Emily R.

AU - Palermo, Joseph J.

AU - Ooi, Chee Y.

AU - Liu, Quin

AU - Lin, Tom K.

AU - Morinville, Veronique D.

AU - McFerron, Brian A.

AU - Husain, Sohail Z.

AU - Himes, Ryan

AU - Heyman, Melvin B.

AU - Gonska, Tanja

AU - Giefer, Matthew J.

AU - Gariepy, Cheryl E.

AU - Freedman, Steven D.

AU - Fishman, Douglas S.

AU - Bellin, Melena D

AU - Barth, Bradley

AU - Abu-El-Haija, Maisam

AU - Lowe, Mark E.

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N2 - Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

AB - Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

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