Impact of noninvasive prenatal testing in regionally dispersed medical centers in the United States

Lawrence D. Platt, Mary Beth Janicki, Tracy Prosen, James D. Goldberg, Joseph Adashek, Reinaldo Figueroa, John Rodis, Wayne Liao, Amy J. Sehnert, Holly L. Snyder, Steven L. Warsof

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objective Noninvasive prenatal testing using cell-free DNA is a new alternative to screen for common fetal aneuploidies. It is not known what impact regional location may play on noninvasive prenatal testing implementation and downstream invasive prenatal procedure use in the United States. Study Design Six different regionally based centers collected data on noninvasive prenatal testing indication and results between February and November 2012, as well as their invasive prenatal procedure rates before and after offering noninvasive prenatal testing. Statistical analyses were performed using the 2-proportion Z-test.

Results Of 1477 patients who underwent noninvasive prenatal testing; 693 (47%) were from centers in the West; 522 (35.3%) from centers in the East; and 262 (17.7%) from 1 center in the Midwest. Statistically significant differences were observed between West Coast and nonWest Coast sites for gestational age (14.1 weeks; P ≤.0001). Advanced maternal age (AMA-only) was the most frequent indication in 5 of 6 sites (range, 21.8-62.9%) A total of 98 invasive prenatal procedures performed on 94 (6.4%) patients of which 64 (65.3%) were performed at centers in the West. More invasive procedures were performed following negative noninvasive prenatal testing results (n = 61) than abnormal noninvasive prenatal testing results (n = 30). The overall rate of patients undergoing invasive procedure after an abnormal noninvasive prenatal testing result was 32.6% (30 of 92). All 6 centers reported a decrease in invasive procedure volume after noninvasive prenatal testing introduction.

Conclusion This study demonstrates differences in clinical implementation of noninvasive prenatal testing across regionally dispersed centers in the United States, suggesting patient demographics and views toward prenatal testing influence use as well as downstream management.

Original languageEnglish (US)
Pages (from-to)368.e1-368.e7
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Oct 1 2014


  • noninvasive prenatal test
  • regional implementation


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