Impact of facility type and volume in low-grade glioma Outcomes

Ping Zhu, Xianglin L. Du, Angel I. Blanco, Leomar Y. Ballester, Nitin Tandon, Mitchel S. Berger, Jay Jiguang Zhu, Yoshua Esquenazi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE The object of this study was to investigate the impact of facility type (academic center [AC] vs non-AC) and facility volume (high-volume facility [HVF] vs low-volume facility [LVF]) on low-grade glioma (LGG) outcomes. METHODS This retrospective cohort study included 5539 LGG patients (2004-2014) from the National Cancer Database. Patients were categorized by facility type and volume (non-AC vs AC, HVF vs LVF). An HVF was defined as the top 1% of facilities according to the number of annual cases. Outcomes included overall survival, treatment receipt, and postoperative outcomes. Kaplan-Meier and Cox proportional-hazards models were applied. The Heller explained relative risk was computed to assess the relative importance of each survival predictor. RESULTS Significant survival advantages were observed at HVFs (HR 0.67, 95% CI 0.55-0.82, p < 0.001) and ACs (HR 0.84, 95% CI 0.73-0.97, p = 0.015), both prior to and after adjusting for all covariates. Tumor resection was 41% and 26% more likely to be performed at HVFs vs LVFs and ACs vs non-ACs, respectively. Chemotherapy was 40% and 88% more frequently to be utilized at HVFs vs LVFs and ACs vs non-ACs, respectively. Prolonged length of stay (LOS) was decreased by 42% and 24% at HVFs and ACs, respectively. After tumor histology, tumor pattern, and codeletion of 1p19q, facility type and surgical procedure were the most important contributors to survival variance. The main findings remained consistent using propensity score matching and multiple imputation. CONCLUSIONS This study provides evidence of survival benefits among LGG patients treated at HVFs and ACs. An increased likelihood of undergoing resections, receiving adjuvant therapies, having shorter LOSs, and the multidisciplinary environment typically found at ACs and HVFs are important contributors to the authors' finding.

Original languageEnglish (US)
Pages (from-to)1313-1323
Number of pages11
JournalJournal of neurosurgery
Volume133
Issue number5
DOIs
StatePublished - Nov 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© AANS 2020, except where prohibited by US copyright law.

Keywords

  • Hospital based
  • Low-grade glioma
  • National cancer database
  • Oncology
  • Overall survival
  • Volume based

PubMed: MeSH publication types

  • Journal Article

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