Impact of diet on hydrogen sulfide production: Implications for gut health

Levi Teigen, Annabel Biruete, Alexander Khoruts

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Purpose of reviewExcessive hydrogen sulfide (H2S) production by the gut microbiota may contribute to the pathogenesis of multiple intestinal diseases, including colon cancer and ulcerative colitis. Therefore, understanding of dietary drivers of H2S production has potential implications for nutritional strategies to optimize gut health and treat intestinal diseases.Recent findingsRecent studies support a positive relationship between dietary protein intake and H2S production. However, protein rarely exists in isolation in the diet, and dietary fiber intake could reduce H2S production in humans and animals, even with ∼30% of calories derived from protein.SummaryThese findings suggest that increased fiber intake may reduce H2S production irrespective of protein intake, enabling the ability to meet the metabolic demands of the illness while supporting gut health. Here we discuss two recent ulcerative colitis diet studies that illustrate this point.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalCurrent opinion in clinical nutrition and metabolic care
Issue number1
StatePublished - Jan 1 2023

Bibliographical note

Funding Information:
L.T. was supported by Achieving Cures Together. A.B. was supported by Indiana CTSI-KL2 (This publication was made possible with support from Grant Numbers, KL2TR002530 (Sheri Robb, PI), and UL1TR002529 (Sarah Wiehe and Sharon Moe, co-PIs) from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award.)

Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.


  • fiber
  • gut microbiota
  • hydrogen sulfide
  • protein


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