Impact of diet on hydrogen sulfide production: Implications for gut health

Levi Teigen; Annabel Biruete; Alexander Khoruts

doi:10.1097/mco.0000000000000881

Impact of diet on hydrogen sulfide production: Implications for gut health

Levi Teigen, Annabel Biruete, Alexander Khoruts

Medicine - Gastro, Hepatology, Nutrition Division

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Purpose of reviewExcessive hydrogen sulfide (H₂S) production by the gut microbiota may contribute to the pathogenesis of multiple intestinal diseases, including colon cancer and ulcerative colitis. Therefore, understanding of dietary drivers of H₂S production has potential implications for nutritional strategies to optimize gut health and treat intestinal diseases.Recent findingsRecent studies support a positive relationship between dietary protein intake and H₂S production. However, protein rarely exists in isolation in the diet, and dietary fiber intake could reduce H₂S production in humans and animals, even with ∼30% of calories derived from protein.SummaryThese findings suggest that increased fiber intake may reduce H₂S production irrespective of protein intake, enabling the ability to meet the metabolic demands of the illness while supporting gut health. Here we discuss two recent ulcerative colitis diet studies that illustrate this point.

Original language	English (US)
Pages (from-to)	55-58
Number of pages	4
Journal	Current opinion in clinical nutrition and metabolic care
Volume	26
Issue number	1
DOIs	https://doi.org/10.1097/mco.0000000000000881
State	Published - Jan 1 2023

Bibliographical note

Funding Information:
L.T. was supported by Achieving Cures Together. A.B. was supported by Indiana CTSI-KL2 (This publication was made possible with support from Grant Numbers, KL2TR002530 (Sheri Robb, PI), and UL1TR002529 (Sarah Wiehe and Sharon Moe, co-PIs) from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award.)

Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.

Keywords

fiber
gut microbiota
hydrogen sulfide
protein

PubMed: MeSH publication types

Review
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/mco.0000000000000881

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abstract = "Purpose of reviewExcessive hydrogen sulfide (H2S) production by the gut microbiota may contribute to the pathogenesis of multiple intestinal diseases, including colon cancer and ulcerative colitis. Therefore, understanding of dietary drivers of H2S production has potential implications for nutritional strategies to optimize gut health and treat intestinal diseases.Recent findingsRecent studies support a positive relationship between dietary protein intake and H2S production. However, protein rarely exists in isolation in the diet, and dietary fiber intake could reduce H2S production in humans and animals, even with ∼30% of calories derived from protein.SummaryThese findings suggest that increased fiber intake may reduce H2S production irrespective of protein intake, enabling the ability to meet the metabolic demands of the illness while supporting gut health. Here we discuss two recent ulcerative colitis diet studies that illustrate this point.",

keywords = "fiber, gut microbiota, hydrogen sulfide, protein",

author = "Levi Teigen and Annabel Biruete and Alexander Khoruts",

note = "Funding Information: L.T. was supported by Achieving Cures Together. A.B. was supported by Indiana CTSI-KL2 (This publication was made possible with support from Grant Numbers, KL2TR002530 (Sheri Robb, PI), and UL1TR002529 (Sarah Wiehe and Sharon Moe, co-PIs) from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award.) Publisher Copyright: {\textcopyright} 2023 Lippincott Williams and Wilkins. All rights reserved.",

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doi = "10.1097/mco.0000000000000881",

language = "English (US)",

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T2 - Implications for gut health

AU - Teigen, Levi

AU - Biruete, Annabel

AU - Khoruts, Alexander

N1 - Funding Information: L.T. was supported by Achieving Cures Together. A.B. was supported by Indiana CTSI-KL2 (This publication was made possible with support from Grant Numbers, KL2TR002530 (Sheri Robb, PI), and UL1TR002529 (Sarah Wiehe and Sharon Moe, co-PIs) from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award.) Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Purpose of reviewExcessive hydrogen sulfide (H2S) production by the gut microbiota may contribute to the pathogenesis of multiple intestinal diseases, including colon cancer and ulcerative colitis. Therefore, understanding of dietary drivers of H2S production has potential implications for nutritional strategies to optimize gut health and treat intestinal diseases.Recent findingsRecent studies support a positive relationship between dietary protein intake and H2S production. However, protein rarely exists in isolation in the diet, and dietary fiber intake could reduce H2S production in humans and animals, even with ∼30% of calories derived from protein.SummaryThese findings suggest that increased fiber intake may reduce H2S production irrespective of protein intake, enabling the ability to meet the metabolic demands of the illness while supporting gut health. Here we discuss two recent ulcerative colitis diet studies that illustrate this point.

AB - Purpose of reviewExcessive hydrogen sulfide (H2S) production by the gut microbiota may contribute to the pathogenesis of multiple intestinal diseases, including colon cancer and ulcerative colitis. Therefore, understanding of dietary drivers of H2S production has potential implications for nutritional strategies to optimize gut health and treat intestinal diseases.Recent findingsRecent studies support a positive relationship between dietary protein intake and H2S production. However, protein rarely exists in isolation in the diet, and dietary fiber intake could reduce H2S production in humans and animals, even with ∼30% of calories derived from protein.SummaryThese findings suggest that increased fiber intake may reduce H2S production irrespective of protein intake, enabling the ability to meet the metabolic demands of the illness while supporting gut health. Here we discuss two recent ulcerative colitis diet studies that illustrate this point.

KW - fiber

KW - gut microbiota

KW - hydrogen sulfide

KW - protein

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Impact of diet on hydrogen sulfide production: Implications for gut health

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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