Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Howard Chertkow; Natalie Phillips; Kenneth Rockwood; Nicole Anderson; Melissa K. Andrew; Robert Bartha; Camille Beaudoin; Nathalie Bélanger; Pierre Bellec; Sylvie Belleville; Howard Bergman; Sarah Best; Jennifer Bethell; Louis Bherer; Sandra Black; Michael Borrie; Richard Camicioli; Julie Carrier; Neil Cashman; Senny Chan; Lynden Crowshoe; Claudio Cuello; Max Cynader; Thanh Dang-Vu; Samir Das; Roger A. Dixon; Simon Ducharme; Gillian Einstein; Alan C. Evans; Margaret Fahnestock; Howard Feldman; Guylaine Ferland; Elizabeth Finger; John D. Fisk; Jennifer Fogarty; Edward Fon; Ziv Gan-Or; Serge Gauthier; Carol Greenwood; Charlie Henri-Bellemare; Nathan Herrmann; David B. Hogan; Robin Hsiung; Inbal Itzhak; Kristen Jacklin; Krista Lanctôt; Andrew Lim; Ian MacKenzie; Mario Masellis; Colleen Maxwell; Carrie McAiney; Katherine McGilton; Jo Anne McLaurin; Alex Mihailidis; Zia Mohades; Manuel Montero-Odasso; Debra Morgan; Gary Naglie; Haakon Nygaard; Megan O'Connell; Ron Petersen; Randi Pilon; Maria Natasha Rajah; Mark Rapoport; Pamela Roach; Julie M. Robillard; Ekaterina Rogaeva; Pedro Rosa-Neto; Jane Rylett; Joel Sadavoy; Peter St George-Hyslop; Dallas Seitz; Eric Smith; Bojana Stefanovic; Isabelle Vedel; Jennifer D. Walker; Cheryl Wellington; Victor Whitehead; Walter Wittich

doi:10.1177/13872877241290990

Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Howard Chertkow, Natalie Phillips, Kenneth Rockwood, Nicole Anderson, Melissa K. Andrew, Robert Bartha, Camille Beaudoin, Nathalie Bélanger, Pierre Bellec, Sylvie Belleville, Howard Bergman, Sarah Best, Jennifer Bethell, Louis Bherer, Sandra Black, Michael Borrie, Richard Camicioli, Julie Carrier, Neil Cashman, Senny ChanLynden Crowshoe, Claudio Cuello, Max Cynader, Thanh Dang-Vu, Samir Das, Roger A. Dixon, Simon Ducharme, Gillian Einstein, Alan C. Evans, Margaret Fahnestock, Howard Feldman, Guylaine Ferland, Elizabeth Finger, John D. Fisk, Jennifer Fogarty, Edward Fon, Ziv Gan-Or, Serge Gauthier, Carol Greenwood, Charlie Henri-Bellemare, Nathan Herrmann, David B. Hogan, Robin Hsiung, Inbal Itzhak, Kristen Jacklin, Krista Lanctôt, Andrew Lim, Ian MacKenzie, Mario Masellis, Colleen Maxwell, Carrie McAiney, Katherine McGilton, Jo Anne McLaurin, Alex Mihailidis, Zia Mohades, Manuel Montero-Odasso, Debra Morgan, Gary Naglie, Haakon Nygaard, Megan O'Connell, Ron Petersen, Randi Pilon, Maria Natasha Rajah, Mark Rapoport, Pamela Roach, Julie M. Robillard, Ekaterina Rogaeva, Pedro Rosa-Neto, Jane Rylett, Joel Sadavoy, Peter St George-Hyslop, Dallas Seitz, Eric Smith, Bojana Stefanovic, Isabelle Vedel, Jennifer D. Walker, Cheryl Wellington, Victor Whitehead, Walter Wittich

Family Medicine and Biobehavioral Health

Research output: Contribution to journal › Review article › peer-review

Abstract

The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles (2014-2019; 2019-2024) have occurred following peer review, and a third cycle (Phase 3) has just begun. A unique construct was mandated, consisting of 20 national teams in Phase I and 19 teams in Phase II (with research topics spanning from basic to clinical science to health resource systems) along with cross-cutting programs to support them. Responding to the needs of researchers within the CCNA teams, a unique sample of 1173 deeply phenotyped patients with various forms of dementia was accrued and studied over eight years (COMPASS-ND). In the second phase of funding (2019-2024), a national dementia prevention program (CAN-THUMBS UP) was set up. In a short time, this prevention program became a member of the World Wide FINGERS prevention consortium. In this article, the challenges, successes, and impacts of CCNA in Canada and internationally are discussed. Short-term deliverables have occurred, along with considerable promise of impacts in the longer term. The creation of synergy, networking, capacity building, engagement of people with lived experience, and economies of scale have contributed to the considerable success of CCNA by all measures. CCNA is evidence that an organized "centrally-organized" approach to dementia research can catalyze important progress nationally and yield significant and measurable results.

Original language	English (US)
Pages (from-to)	535-561
Number of pages	27
Journal	Journal of Alzheimer's disease : JAD
Volume	102
Issue number	3
DOIs	https://doi.org/10.1177/13872877241290990
State	Published - Dec 1 2024

Keywords

Alzheimer's disease
cohort
dementia
prevention
research plan
sex
synergy

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10.1177/13872877241290990

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Chertkow, H., Phillips, N., Rockwood, K., Anderson, N., Andrew, M. K., Bartha, R., Beaudoin, C., Bélanger, N., Bellec, P., Belleville, S., Bergman, H., Best, S., Bethell, J., Bherer, L., Black, S., Borrie, M., Camicioli, R., Carrier, J., Cashman, N., ... Wittich, W. (2024). Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA). Journal of Alzheimer's disease : JAD, 102(3), 535-561. https://doi.org/10.1177/13872877241290990

Chertkow, H, Phillips, N, Rockwood, K, Anderson, N, Andrew, MK, Bartha, R, Beaudoin, C, Bélanger, N, Bellec, P, Belleville, S, Bergman, H, Best, S, Bethell, J, Bherer, L, Black, S, Borrie, M, Camicioli, R, Carrier, J, Cashman, N, Chan, S, Crowshoe, L, Cuello, C, Cynader, M, Dang-Vu, T, Das, S, Dixon, RA, Ducharme, S, Einstein, G, Evans, AC, Fahnestock, M, Feldman, H, Ferland, G, Finger, E, Fisk, JD, Fogarty, J, Fon, E, Gan-Or, Z, Gauthier, S, Greenwood, C, Henri-Bellemare, C, Herrmann, N, Hogan, DB, Hsiung, R, Itzhak, I, Jacklin, K, Lanctôt, K, Lim, A, MacKenzie, I, Masellis, M, Maxwell, C, McAiney, C, McGilton, K, McLaurin, JA, Mihailidis, A, Mohades, Z, Montero-Odasso, M, Morgan, D, Naglie, G, Nygaard, H, O'Connell, M, Petersen, R, Pilon, R, Rajah, MN, Rapoport, M, Roach, P, Robillard, JM, Rogaeva, E, Rosa-Neto, P, Rylett, J, Sadavoy, J, St George-Hyslop, P, Seitz, D, Smith, E, Stefanovic, B, Vedel, I, Walker, JD, Wellington, C, Whitehead, V & Wittich, W 2024, 'Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)', Journal of Alzheimer's disease : JAD, vol. 102, no. 3, pp. 535-561. https://doi.org/10.1177/13872877241290990

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title = "Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)",

abstract = "The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles (2014-2019; 2019-2024) have occurred following peer review, and a third cycle (Phase 3) has just begun. A unique construct was mandated, consisting of 20 national teams in Phase I and 19 teams in Phase II (with research topics spanning from basic to clinical science to health resource systems) along with cross-cutting programs to support them. Responding to the needs of researchers within the CCNA teams, a unique sample of 1173 deeply phenotyped patients with various forms of dementia was accrued and studied over eight years (COMPASS-ND). In the second phase of funding (2019-2024), a national dementia prevention program (CAN-THUMBS UP) was set up. In a short time, this prevention program became a member of the World Wide FINGERS prevention consortium. In this article, the challenges, successes, and impacts of CCNA in Canada and internationally are discussed. Short-term deliverables have occurred, along with considerable promise of impacts in the longer term. The creation of synergy, networking, capacity building, engagement of people with lived experience, and economies of scale have contributed to the considerable success of CCNA by all measures. CCNA is evidence that an organized {"}centrally-organized{"} approach to dementia research can catalyze important progress nationally and yield significant and measurable results.",

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author = "Howard Chertkow and Natalie Phillips and Kenneth Rockwood and Nicole Anderson and Andrew, {Melissa K.} and Robert Bartha and Camille Beaudoin and Nathalie B{\'e}langer and Pierre Bellec and Sylvie Belleville and Howard Bergman and Sarah Best and Jennifer Bethell and Louis Bherer and Sandra Black and Michael Borrie and Richard Camicioli and Julie Carrier and Neil Cashman and Senny Chan and Lynden Crowshoe and Claudio Cuello and Max Cynader and Thanh Dang-Vu and Samir Das and Dixon, {Roger A.} and Simon Ducharme and Gillian Einstein and Evans, {Alan C.} and Margaret Fahnestock and Howard Feldman and Guylaine Ferland and Elizabeth Finger and Fisk, {John D.} and Jennifer Fogarty and Edward Fon and Ziv Gan-Or and Serge Gauthier and Carol Greenwood and Charlie Henri-Bellemare and Nathan Herrmann and Hogan, {David B.} and Robin Hsiung and Inbal Itzhak and Kristen Jacklin and Krista Lanct{\^o}t and Andrew Lim and Ian MacKenzie and Mario Masellis and Colleen Maxwell and Carrie McAiney and Katherine McGilton and McLaurin, {Jo Anne} and Alex Mihailidis and Zia Mohades and Manuel Montero-Odasso and Debra Morgan and Gary Naglie and Haakon Nygaard and Megan O'Connell and Ron Petersen and Randi Pilon and Rajah, {Maria Natasha} and Mark Rapoport and Pamela Roach and Robillard, {Julie M.} and Ekaterina Rogaeva and Pedro Rosa-Neto and Jane Rylett and Joel Sadavoy and {St George-Hyslop}, Peter and Dallas Seitz and Eric Smith and Bojana Stefanovic and Isabelle Vedel and Walker, {Jennifer D.} and Cheryl Wellington and Victor Whitehead and Walter Wittich",

year = "2024",

month = dec,

day = "1",

doi = "10.1177/13872877241290990",

language = "English (US)",

volume = "102",

pages = "535--561",

journal = "Journal of Alzheimer's disease : JAD",

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AU - Chertkow, Howard

AU - Phillips, Natalie

AU - Rockwood, Kenneth

AU - Anderson, Nicole

AU - Andrew, Melissa K.

AU - Bartha, Robert

AU - Beaudoin, Camille

AU - Bélanger, Nathalie

AU - Bellec, Pierre

AU - Belleville, Sylvie

AU - Bergman, Howard

AU - Best, Sarah

AU - Bethell, Jennifer

AU - Bherer, Louis

AU - Black, Sandra

AU - Borrie, Michael

AU - Camicioli, Richard

AU - Carrier, Julie

AU - Cashman, Neil

AU - Chan, Senny

AU - Crowshoe, Lynden

AU - Cuello, Claudio

AU - Cynader, Max

AU - Dang-Vu, Thanh

AU - Das, Samir

AU - Dixon, Roger A.

AU - Ducharme, Simon

AU - Einstein, Gillian

AU - Evans, Alan C.

AU - Fahnestock, Margaret

AU - Feldman, Howard

AU - Ferland, Guylaine

AU - Finger, Elizabeth

AU - Fisk, John D.

AU - Fogarty, Jennifer

AU - Fon, Edward

AU - Gan-Or, Ziv

AU - Gauthier, Serge

AU - Greenwood, Carol

AU - Henri-Bellemare, Charlie

AU - Herrmann, Nathan

AU - Hogan, David B.

AU - Hsiung, Robin

AU - Itzhak, Inbal

AU - Jacklin, Kristen

AU - Lanctôt, Krista

AU - Lim, Andrew

AU - MacKenzie, Ian

AU - Masellis, Mario

AU - Maxwell, Colleen

AU - McAiney, Carrie

AU - McGilton, Katherine

AU - McLaurin, Jo Anne

AU - Mihailidis, Alex

AU - Mohades, Zia

AU - Montero-Odasso, Manuel

AU - Morgan, Debra

AU - Naglie, Gary

AU - Nygaard, Haakon

AU - O'Connell, Megan

AU - Petersen, Ron

AU - Pilon, Randi

AU - Rajah, Maria Natasha

AU - Rapoport, Mark

AU - Roach, Pamela

AU - Robillard, Julie M.

AU - Rogaeva, Ekaterina

AU - Rosa-Neto, Pedro

AU - Rylett, Jane

AU - Sadavoy, Joel

AU - St George-Hyslop, Peter

AU - Seitz, Dallas

AU - Smith, Eric

AU - Stefanovic, Bojana

AU - Vedel, Isabelle

AU - Walker, Jennifer D.

AU - Wellington, Cheryl

AU - Whitehead, Victor

AU - Wittich, Walter

PY - 2024/12/1

Y1 - 2024/12/1

N2 - The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles (2014-2019; 2019-2024) have occurred following peer review, and a third cycle (Phase 3) has just begun. A unique construct was mandated, consisting of 20 national teams in Phase I and 19 teams in Phase II (with research topics spanning from basic to clinical science to health resource systems) along with cross-cutting programs to support them. Responding to the needs of researchers within the CCNA teams, a unique sample of 1173 deeply phenotyped patients with various forms of dementia was accrued and studied over eight years (COMPASS-ND). In the second phase of funding (2019-2024), a national dementia prevention program (CAN-THUMBS UP) was set up. In a short time, this prevention program became a member of the World Wide FINGERS prevention consortium. In this article, the challenges, successes, and impacts of CCNA in Canada and internationally are discussed. Short-term deliverables have occurred, along with considerable promise of impacts in the longer term. The creation of synergy, networking, capacity building, engagement of people with lived experience, and economies of scale have contributed to the considerable success of CCNA by all measures. CCNA is evidence that an organized "centrally-organized" approach to dementia research can catalyze important progress nationally and yield significant and measurable results.

AB - The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles (2014-2019; 2019-2024) have occurred following peer review, and a third cycle (Phase 3) has just begun. A unique construct was mandated, consisting of 20 national teams in Phase I and 19 teams in Phase II (with research topics spanning from basic to clinical science to health resource systems) along with cross-cutting programs to support them. Responding to the needs of researchers within the CCNA teams, a unique sample of 1173 deeply phenotyped patients with various forms of dementia was accrued and studied over eight years (COMPASS-ND). In the second phase of funding (2019-2024), a national dementia prevention program (CAN-THUMBS UP) was set up. In a short time, this prevention program became a member of the World Wide FINGERS prevention consortium. In this article, the challenges, successes, and impacts of CCNA in Canada and internationally are discussed. Short-term deliverables have occurred, along with considerable promise of impacts in the longer term. The creation of synergy, networking, capacity building, engagement of people with lived experience, and economies of scale have contributed to the considerable success of CCNA by all measures. CCNA is evidence that an organized "centrally-organized" approach to dementia research can catalyze important progress nationally and yield significant and measurable results.

KW - Alzheimer's disease

KW - cohort

KW - dementia

KW - prevention

KW - research plan

KW - sex

KW - synergy

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ER -

Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

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