Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate

Jean Paul Cano, Scott A. Dee, Michael P. Murtaugh, Carlos Pijoan

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The objectives of this study were to evaluate the effects of a therapeutic vaccine intervention with a modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine on the dynamics of a heterologous viral infection in a population of pigs, and to determine the clinical and virological response of previously exposed and vaccinated pigs against a second virulent heterologous challenge. A population of 320 pigs were infected with a field isolate, PRRSV MN-30100, alone or followed by Ingelvac® PRRS MLV vaccine administered one to three times at 30 days intervals beginning 1 week after infection. Vaccine intervention reduced the duration of viral shedding, but did not reduce the viral load in tissues or the proportion of persistently infected pigs. A different and highly virulent field isolate, MN-184, was then given as a heterologous viral challenge at 97 days after first exposure. Previously infected and vaccinated pigs showed a significant reduction in clinical signs and enhanced weight gain after the highly virulent challenge with PRRSV MN-184, but infection with and shedding of the challenge isolate were not prevented.

Original languageEnglish (US)
Pages (from-to)4382-4391
Number of pages10
JournalVaccine
Volume25
Issue number22
DOIs
StatePublished - May 30 2007

Keywords

  • Heterologous infection
  • MLV vaccine
  • Mass vaccination
  • PRRSV
  • Swine

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