Immunovirotherapy for the treatment of glioblastoma

Tooba A. Cheema, Peter E. Fecci, Jianfang Ning, Samuel D. Rabkin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47Δ-IL12.

Original languageEnglish (US)
Article numbere27218
JournalOncoImmunology
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Cancer stem cells
  • Glioma
  • Herpes simplex virus
  • Interleukin-12
  • Oncolytic virus
  • Treg

Fingerprint Dive into the research topics of 'Immunovirotherapy for the treatment of glioblastoma'. Together they form a unique fingerprint.

Cite this