Immunovirotherapy for the treatment of glioblastoma

Tooba A. Cheema, Peter E. Fecci, Jianfang Ning, Samuel D. Rabkin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47Δ-IL12.

Original languageEnglish (US)
Article numbere27218
Issue number1
StatePublished - 2014
Externally publishedYes


  • Cancer stem cells
  • Glioma
  • Herpes simplex virus
  • Interleukin-12
  • Oncolytic virus
  • Treg


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