Immunotoxin therapy for CNS tumor

Edward Rustamzadeh; Walter C. Low; Daniel A. Vallera; Walter A. Hall

doi:10.1023/A:1024906516075

Immunotoxin therapy for CNS tumor

Edward Rustamzadeh, Walter C. Low, Daniel A. Vallera, Walter A. Hall

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Surgery, chemotherapy, and radiation therapy have become standard of practice in treating malignant brain tumors. Unfortunately, the prognosis of these malignant tumors still remains poor. Immunotoxins are a relatively new adjuvant treatment for brain tumors. Within the last few years an increased amount of clinically-oriented research involving immunotoxins has been published. This has led to numerous clinical trials which although encouraging have not yet born out the "magic bullet" concept envisioned for immunotoxins. In this review article the history, design, toxicity, and pharmokinetics of immunotoxins will be discussed in detail.

Original language	English (US)
Pages (from-to)	101-116
Number of pages	16
Journal	Journal of neuro-oncology
Volume	64
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1024906516075
State	Published - Aug 1 2003

Keywords

Anaplastic astrocytoma
Glioblastoma multiforme
Immunotoxin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1024906516075

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abstract = "Surgery, chemotherapy, and radiation therapy have become standard of practice in treating malignant brain tumors. Unfortunately, the prognosis of these malignant tumors still remains poor. Immunotoxins are a relatively new adjuvant treatment for brain tumors. Within the last few years an increased amount of clinically-oriented research involving immunotoxins has been published. This has led to numerous clinical trials which although encouraging have not yet born out the {"}magic bullet{"} concept envisioned for immunotoxins. In this review article the history, design, toxicity, and pharmokinetics of immunotoxins will be discussed in detail.",

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AU - Vallera, Daniel A.

AU - Hall, Walter A.

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AB - Surgery, chemotherapy, and radiation therapy have become standard of practice in treating malignant brain tumors. Unfortunately, the prognosis of these malignant tumors still remains poor. Immunotoxins are a relatively new adjuvant treatment for brain tumors. Within the last few years an increased amount of clinically-oriented research involving immunotoxins has been published. This has led to numerous clinical trials which although encouraging have not yet born out the "magic bullet" concept envisioned for immunotoxins. In this review article the history, design, toxicity, and pharmokinetics of immunotoxins will be discussed in detail.

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Immunotoxin therapy for CNS tumor

Abstract

Keywords

UN SDGs

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