Immunotherapy of collagen-induced arthritis by a T-cell antiproliferative molecule

Donna J. Spannaus-Martin, Rikard Holmdahl, Thomas F. Kresina

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The present study describes a novel experimental immunotherapeutic methodology for the reduction of inflammatory synovitis that is noted in an animal model of rheumatoid arthritis. The reduction in inflammation is noted in the animals administered a contra-interleukin-2 (IL-2) cytokine secreted by a cloned T-cell line. The mechanism of reduction of inflammation by this cytokine is through the inhibition of activation and differentiation of T lymphocytes. The cytokine inhibits the in vitro mitogen activation of T-cell lymphocytes as well as antigen-specific activation of a collagen type II specific T-cell line. In addition, decreased levels of messenger RNA coding for interleukin-2 are noted in T lymphocytes and IL-2 activation of the collagen type II specific cell line is inhibited by the contra-IL-2 cytokine. This initial description of a reduction in inflammation by a contra-IL-2 lymphokine suggests that immunoregulatory biologic molecules that are antagonists to IL-2 may be useful for the experimental immunotherapy of cartilage connective tissue pathology.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalAmerican Journal of Pathology
Volume137
Issue number2
StatePublished - 1990

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