Immunotherapy of a murine sarcoma using specific antitumor immune RNA

D. J.T. Webster; J. B. Cornacoff; D. A. Vallera; J. P. Dalmasso; M. C. Dodd; J. P. Minton

doi:10.1002/jso.2930120305

Immunotherapy of a murine sarcoma using specific antitumor immune RNA

D. J.T. Webster
, J. B. Cornacoff
, D. A. Vallera
, J. P. Dalmasso
, M. C. Dodd
, J. P. Minton

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C₃H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

Original language	English (US)
Pages (from-to)	213-220
Number of pages	8
Journal	Journal of Surgical Oncology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/jso.2930120305
State	Published - 1979

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

immune RNA
immunotherapy
murine sarcoma

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10.1002/jso.2930120305

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title = "Immunotherapy of a murine sarcoma using specific antitumor immune RNA",

abstract = "The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.",

keywords = "immune RNA, immunotherapy, murine sarcoma",

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year = "1979",

doi = "10.1002/jso.2930120305",

language = "English (US)",

volume = "12",

pages = "213--220",

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T1 - Immunotherapy of a murine sarcoma using specific antitumor immune RNA

AU - Webster, D. J.T.

AU - Cornacoff, J. B.

AU - Vallera, D. A.

AU - Dalmasso, J. P.

AU - Dodd, M. C.

AU - Minton, J. P.

PY - 1979

Y1 - 1979

N2 - The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

AB - The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

KW - immune RNA

KW - immunotherapy

KW - murine sarcoma

UR - https://www.scopus.com/pages/publications/0018601173

UR - https://www.scopus.com/pages/publications/0018601173#tab=citedBy

U2 - 10.1002/jso.2930120305

DO - 10.1002/jso.2930120305

M3 - Article

C2 - 502564

AN - SCOPUS:0018601173

SN - 0022-4790

VL - 12

SP - 213

EP - 220

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 3

ER -

Immunotherapy of a murine sarcoma using specific antitumor immune RNA

Abstract

UN SDGs

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