Abstract
The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.
Original language | English (US) |
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Pages (from-to) | 213-220 |
Number of pages | 8 |
Journal | Journal of Surgical Oncology |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - 1979 |
Keywords
- immune RNA
- immunotherapy
- murine sarcoma