Immunotherapy of a murine sarcoma using specific antitumor immune RNA

D. J.T. Webster, J. B. Cornacoff, D. A. Vallera, J. P. Dalmasso, M. C. Dodd, J. P. Minton

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalJournal of Surgical Oncology
Volume12
Issue number3
DOIs
StatePublished - 1979

Keywords

  • immune RNA
  • immunotherapy
  • murine sarcoma

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