Immunosuppressive Properties of Calcium Channel Blockers

Kerri K. Chitwood, Karen L Heim-Duthoy

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are independent of their effects on the cardiovascular system. Indeed, both in vitro and in vivo studies suggested that they may possess immunosuppressive properties. Their actions at the cellular level in both the afferent and efferent arms of the immune system indicate that alone, as well as in combination with cyclosporine, these agents possess immunosuppressive properties that may potentially benefit the transplant population. 1993 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)447-454
Number of pages8
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number5
StatePublished - 1993


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