TY - JOUR
T1 - Immunosuppressive Properties of Calcium Channel Blockers
AU - Chitwood, Kerri K.
AU - Heim-Duthoy, Karen L
PY - 1993
Y1 - 1993
N2 - Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are independent of their effects on the cardiovascular system. Indeed, both in vitro and in vivo studies suggested that they may possess immunosuppressive properties. Their actions at the cellular level in both the afferent and efferent arms of the immune system indicate that alone, as well as in combination with cyclosporine, these agents possess immunosuppressive properties that may potentially benefit the transplant population. 1993 Pharmacotherapy Publications Inc.
AB - Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are independent of their effects on the cardiovascular system. Indeed, both in vitro and in vivo studies suggested that they may possess immunosuppressive properties. Their actions at the cellular level in both the afferent and efferent arms of the immune system indicate that alone, as well as in combination with cyclosporine, these agents possess immunosuppressive properties that may potentially benefit the transplant population. 1993 Pharmacotherapy Publications Inc.
UR - http://www.scopus.com/inward/record.url?scp=0027493428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027493428&partnerID=8YFLogxK
U2 - 10.1002/j.1875-9114.1993.tb04305.x
DO - 10.1002/j.1875-9114.1993.tb04305.x
M3 - Review article
C2 - 8247910
AN - SCOPUS:0027493428
SN - 0277-0008
VL - 13
SP - 447
EP - 454
JO - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
JF - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
IS - 5
ER -