Immunoprophylaxis of an ocular solid malignant tumor in cattle

S. J. Kleinschuster, H. J. Rapp, J. Bier, C. C. Muscoplat, R. A. Smart, K. R. Van Kampen

Research output: Contribution to journalArticlepeer-review


Individual Hereford cows bearing benign precursor lesions of ocular squamous cell carcinoma were treated by intralesional injection of mycobacterial cell walls in an oil-in-water emulsion in an attempt to interrupt neoplastic progression. Thirty-one months after treatment, statistical analysis of data indicated that intralesional BCG cell wall vaccine can interrupt this proces and provides effective immunoprophylactic prevention of malignant disease.

Original languageEnglish (US)
Pages (from-to)771-776
Number of pages6
JournalJournal of the National Cancer Institute
Issue number4
StatePublished - 1983


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