Immunopathology of Ascarid Infection of the Eye: Role of IgE Antibodies and Mast Cells

John H. Rockey, John J. Donnelly, Bert E. Stromberg, Alan M. Laties, E. J.L. Soulsby

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The roles of IgE antiascarid antibodies and mast cells were compared in passively sensitized guinea pigs and animals infected intravitreally with ascarid larvae (Toxocara canis, Ascaris suum). Intravenous IgE antibody disappeared from the serum within 48 hours, but induced a hypersensitive state that persisted for 28 days. In systemically immunized animals, the aqueous-serum IgE antibody ratio was 1:1,000 or less. Passive periocular anaphylactic reactions produced an infiltration of neutrophils and eosinophils, degranulation of mast cells, and vascular leakage in periocular and episcleral tissues. Systemic anaphylaxis also produced degranulation of uveal mast cells, an infiltration of eosinophils, and vascular leakage in the choroid. Intraocular infection produced a transient decrease of mast cells that correlated with an increased infiltration of eosinophils and plasma cells.

Original languageEnglish (US)
Pages (from-to)1831-1840
Number of pages10
JournalArchives of Ophthalmology
Volume99
Issue number10
DOIs
StatePublished - Oct 1981

Bibliographical note

Funding Information:
ThisstudywassupportedbyPublicHealth Service researchgrantsAI06262,AI11719, EY00305,EY01193,andEY01194andbiomedicai researchsupportgrantRR05615;byaFightfor Sight Student Fellowship financed by a grant fromBurroughsWellcomeCoandaFightfor SightPostdoctoralResearchFellowship(DrDon¬ nelly);byanunrestrictedgrantfromResearchto PreventBlindness,Ine;andbytheHarryand EdithHubschmanResearchFund. LawrenceT.Glickman,VMD,providedthe infectiveeggsofToxocaracanis.NormaMolina and Derek W.Munceyassistedinpreparingthe parasites.MaryHamill,LouisH.Andrews,Bar¬ baraBriggs,AliceMcGlinn,NestorG.Menocal, andDoloresB.Venturaassistedinpreparingthe histologiespecimens.

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