Immunomodulation via lentiviral delivery from microporous scaffolds alters metastatic tumor cell recruitment in vivo

Grace G. Bushnell, Shreyas S. Rao, Rachel M. Hartfield, Yining Zhang, Robert S. Oakes, Jacqueline S. Jeruss, Lonnie D. Shea

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: In most types of cancer, the formation of distant metastasis is the point at which clinical treatment shifts from curative intent to palliative care. At present, there is no clinical method to detect metastatic dissemination and colonization of distal sites until radiologically evident, at which point organ function has often already been compromised. The Shea and Jeruss laboratories have developed a biomaterial implant that recruits metastatic cancer cells in xenogeneic human and syngeneic mouse models of breast cancer (1-3). While immune cells associated with the scaffold are associated with recruitment, (2), the relative contributions of individual cytokines to immune cell and subsequent tumor cell recruitment at the pre-metastatic niche is unknown.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages109
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

Bibliographical note

Publisher Copyright:
© 2019 Omnipress - All rights reserved.

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