Immunology of type 1 diabetes: Intervention and prevention strategies

S. Bertera, A. Alexander, N. Giannoukakis, P. D. Robbins, M. Trucco

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Type 1 diabetes is the outcome of a progressive and selective destruction of insulin-producing cells in the pancreatic islets of Langerhans. The precise cause and mechanism(s) that trigger the insulin- producing cell destruction are still unclear, although it is well accepted that an autoimmune process plays a central role in diabetes development among genetically susceptible children. Additionally, certain viral infections, especially those caused by Coxsackievirus B, have been associated with the onset of type 1 diabetes. Possible gene therapy-based prevention and intervention strategies are discussed, based on the most accepted models of type 1 diabetes pathogenesis.

Original languageEnglish (US)
Pages (from-to)841-864
Number of pages24
JournalEndocrinology and Metabolism Clinics of North America
Issue number4
StatePublished - 1999
Externally publishedYes


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