Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)

David A. Hafler; Sally C. Kent; Yahua Chen; Lisa Bregoli; Sue M. Clemmings; Hering Bernhard; Kenyon Norma Sue; Ricordi Camillo

doi:10.1038/nature04424

Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)

David A. Hafler
, Sally C. Kent
, Yahua Chen
, Lisa Bregoli
, Sue M. Clemmings
, Hering Bernhard
, Kenyon Norma Sue
, Ricordi Camillo

Surgery

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clones and their degree of responsiveness.

Original language	English (US)
Pages (from-to)	E5-E6
Journal	Nature
Volume	438
Issue number	7067
DOIs	https://doi.org/10.1038/nature04424
State	Published - Nov 24 2005

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SDG 3 Good Health and Well-being

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10.1038/nature04424

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title = "Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)",

abstract = "Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clones and their degree of responsiveness.",

author = "Hafler, \{David A.\} and Kent, \{Sally C.\} and Yahua Chen and Lisa Bregoli and Clemmings, \{Sue M.\} and Hering Bernhard and \{Norma Sue\}, Kenyon and Ricordi Camillo",

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AU - Hafler, David A.

AU - Kent, Sally C.

AU - Chen, Yahua

AU - Bregoli, Lisa

AU - Clemmings, Sue M.

AU - Bernhard, Hering

AU - Norma Sue, Kenyon

AU - Camillo, Ricordi

PY - 2005/11/24

Y1 - 2005/11/24

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AB - Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clones and their degree of responsiveness.

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SP - E5-E6

JO - Nature

JF - Nature

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ER -

Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)

Abstract

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