Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)

David A. Hafler; Sally C. Kent; Yahua Chen; Lisa Bregoli; Sue M. Clemmings; Hering Bernhard; Kenyon Norma Sue; Ricordi Camillo

doi:10.1038/nature04424

Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)

David A. Hafler, Sally C. Kent, Yahua Chen, Lisa Bregoli, Sue M. Clemmings, Hering Bernhard, Kenyon Norma Sue, Ricordi Camillo

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Abstract

Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clones and their degree of responsiveness.

Original language	English (US)
Pages (from-to)	E5-E6
Journal	Nature
Volume	438
Issue number	7067
DOIs	https://doi.org/10.1038/nature04424
State	Published - Nov 24 2005

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abstract = "Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clones and their degree of responsiveness.",

author = "Hafler, {David A.} and Kent, {Sally C.} and Yahua Chen and Lisa Bregoli and Clemmings, {Sue M.} and Hering Bernhard and {Norma Sue}, Kenyon and Ricordi Camillo",

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AU - Bregoli, Lisa

AU - Clemmings, Sue M.

AU - Bernhard, Hering

AU - Norma Sue, Kenyon

AU - Camillo, Ricordi

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Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply)

Abstract

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