Immunologically mediated fatigue: A murine model

Chun C. Chao, Michael DeLaHunt, Shuxian Hu, Karen Close, Phillip K. Peterson

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Chronic fatigue syndrome (CFS) is an idiopathic disorder in which the chief symptom is profound fatigue. To explore the relationship between immune stimulation and fatigue, we developed a murine model for quantifying fatigue: reduction in voluntary running and delayed initiation of grooming after swimming. Inoculation of female BALB c mice with Corynebacterium parvum antigen or the relatively avirulent Me49 strain of Toxoplasma gondii induced fatigue: baseline running reduced to less than 50 and 30% for 8 and 14 days, respectively, and delayed initiation of grooming after swimming in both immunologically stimulated groups. A threefold evaluation of serum transforming growth factor-β levels, a cytokine increased in CFS patients, was found in fatigued C. parvum- and T. gondii-inoculated mice. This murine model appears promising for investigation of the pathogenesis of immunologically mediated fatigue.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalClinical Immunology and Immunopathology
Volume64
Issue number2
DOIs
StatePublished - Aug 1992
Externally publishedYes

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