Immunologic and ultrastructural heterogeneity of acute lymphoblastic leukemia-associated antigen-positive human leukemias

T. W. LeBien, J. L. Parkin, R. D. Brunning, J. H. Kersey

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

To further examine the heterogeneity of human acute lymphoblastic leukemia, an immunologic and ultrastructural study was undertaken on 14 patients positive for the acute lymphoblastic leukemia-associated antigen (ALLA). In malignant cells from 7 of the patients studied, cytoplasmic granular inclusions that resembled those seen in leukemia mast cells and basophils (M-B granules) were evident. Four patients had malignant cells expressing the pre-B-cell phenotype (i.e., cytoplasmic IgM-positive and surface immunoglobulin-negative), and 3 patients had malignant cells that lacked both M-B granules and cytoplasmic IgM. These results support the existence of distinct phenotypic subgroups within the ALLA leukemias.

Original languageEnglish (US)
Pages (from-to)1231-1236
Number of pages6
JournalJournal of the National Cancer Institute
Volume65
Issue number6
StatePublished - 1980

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