Immunolocalization of NFATc4 in the adult mouse brain

Katherine C. Bradley, Rachel D. Groth, Paul G. Mermelstein

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

NFATc4 has recently been identified as playing an important role in variety of activity-dependent neuronal processes, including hippocampal plasticity, axonal growth, neuronal survival, and apoptosis. However, a systematic study examining the distribution of NFATc4 within the nervous system has yet to be conducted. With this in mind, we sought to determine the regional localization of NFATc4 within the adult mouse brain. Interestingly, NFATc4 was expressed broadly, but not uniformly, throughout various brain structures. The highest levels of NFATc4 expression were localized to the hippocampus, olfactory bulb, and various hypothalamic nuclei. Other brain regions that expressed NFATc4 included the cerebellum, striatum, globus pallidus, amygdala, neocortex, and brainstem nuclei. Given NFATc4's widespread expression, these results are consistent with the notion that NFATc4 may underlie activity-dependent neuronal plasticity throughout the adult brain.

Original languageEnglish (US)
Pages (from-to)762-770
Number of pages9
JournalJournal of Neuroscience Research
Volume82
Issue number6
DOIs
StatePublished - Dec 15 2005

Keywords

  • Calcineurin
  • Hippocampus
  • Hypothalamus
  • NFAT
  • Olfactory bulb
  • Plasticity

Fingerprint Dive into the research topics of 'Immunolocalization of NFATc4 in the adult mouse brain'. Together they form a unique fingerprint.

Cite this