TY - JOUR
T1 - Immunolocalization of NFATc4 in the adult mouse brain
AU - Bradley, Katherine C.
AU - Groth, Rachel D.
AU - Mermelstein, Paul G.
PY - 2005/12/15
Y1 - 2005/12/15
N2 - NFATc4 has recently been identified as playing an important role in variety of activity-dependent neuronal processes, including hippocampal plasticity, axonal growth, neuronal survival, and apoptosis. However, a systematic study examining the distribution of NFATc4 within the nervous system has yet to be conducted. With this in mind, we sought to determine the regional localization of NFATc4 within the adult mouse brain. Interestingly, NFATc4 was expressed broadly, but not uniformly, throughout various brain structures. The highest levels of NFATc4 expression were localized to the hippocampus, olfactory bulb, and various hypothalamic nuclei. Other brain regions that expressed NFATc4 included the cerebellum, striatum, globus pallidus, amygdala, neocortex, and brainstem nuclei. Given NFATc4's widespread expression, these results are consistent with the notion that NFATc4 may underlie activity-dependent neuronal plasticity throughout the adult brain.
AB - NFATc4 has recently been identified as playing an important role in variety of activity-dependent neuronal processes, including hippocampal plasticity, axonal growth, neuronal survival, and apoptosis. However, a systematic study examining the distribution of NFATc4 within the nervous system has yet to be conducted. With this in mind, we sought to determine the regional localization of NFATc4 within the adult mouse brain. Interestingly, NFATc4 was expressed broadly, but not uniformly, throughout various brain structures. The highest levels of NFATc4 expression were localized to the hippocampus, olfactory bulb, and various hypothalamic nuclei. Other brain regions that expressed NFATc4 included the cerebellum, striatum, globus pallidus, amygdala, neocortex, and brainstem nuclei. Given NFATc4's widespread expression, these results are consistent with the notion that NFATc4 may underlie activity-dependent neuronal plasticity throughout the adult brain.
KW - Calcineurin
KW - Hippocampus
KW - Hypothalamus
KW - NFAT
KW - Olfactory bulb
KW - Plasticity
UR - http://www.scopus.com/inward/record.url?scp=28544433316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28544433316&partnerID=8YFLogxK
U2 - 10.1002/jnr.20695
DO - 10.1002/jnr.20695
M3 - Article
C2 - 16273547
AN - SCOPUS:28544433316
SN - 0360-4012
VL - 82
SP - 762
EP - 770
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
IS - 6
ER -