TY - JOUR
T1 - Immunoglobulin levels in workers exposed to hexachlorobenzene
AU - Queiroz, M. L.S.
AU - Bincoletto, C.
AU - Perlingeiro, R. C.R.
AU - Quadros, M. R.
AU - Souza, C. A.
PY - 1998/3
Y1 - 1998/3
N2 - The serum immunoglobulin (IgG, IgM and IgA) concentrations of 52 chlorinated-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had mean hexachlorobenzene (HCB) blood levels of 3.84 μg/dl with a range of 0.1 to 16 μg/dl. Increased IgG and IgM levels were found in the HCB-exposed workers (P < 0.05 and P < 0.01, respectively). Hepatic function was evaluated by serum aspartate (AST) and alanine aminotransferase (ALT) activities, as well as by bilirubin levels. IgM concentrations were positively correlated with three of the studied parameters, namely, length of exposure (r = 0.367) and the activities of both AST (r = 0.367) and ALT (r = 0.507).
AB - The serum immunoglobulin (IgG, IgM and IgA) concentrations of 52 chlorinated-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had mean hexachlorobenzene (HCB) blood levels of 3.84 μg/dl with a range of 0.1 to 16 μg/dl. Increased IgG and IgM levels were found in the HCB-exposed workers (P < 0.05 and P < 0.01, respectively). Hepatic function was evaluated by serum aspartate (AST) and alanine aminotransferase (ALT) activities, as well as by bilirubin levels. IgM concentrations were positively correlated with three of the studied parameters, namely, length of exposure (r = 0.367) and the activities of both AST (r = 0.367) and ALT (r = 0.507).
KW - Hepatic function
KW - Hexachlorobenzene
KW - Immunoglobulin levels
KW - Occupational exposure
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U2 - 10.1191/096032798678908477
DO - 10.1191/096032798678908477
M3 - Article
C2 - 9587786
AN - SCOPUS:0031918380
SN - 0960-3271
VL - 17
SP - 172
EP - 175
JO - Human and Experimental Toxicology
JF - Human and Experimental Toxicology
IS - 3
ER -