Immunoglgbulin levels and cellular immune function in lead exposed workers

M. L S Queiroz, R. C R Perlingeiro, C. Bincoletto, M. Almeida, M. P. Cardoso, D. C M Dantas

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The immunological status of lead acid batters workers with blood lead levels and urinary delta-aminolevulinic acid (ALA-U) concentrations ranging from safe to toxic levels has been examined and compared with those of non-exposed, age and sex matched controls. No differences in the serum concentrations of IgG, IgA and IgM between the populations were observed and there existed no correlation between blood lead level or ALA-U concentrations and serum immunoglobulin levels. In addition assessment was made of the capacity of peripheral blood mononuclear cells to respond to the mitogen phytohaemagglutin in (PHA), a correlate of T cell function. As before, there was no difference between exposed and control populations and no correlation between reactivity and blood lead concentration. Our data suggest that chronic exposure to lead fail to compromise lymphocyte function in man.

Original languageEnglish (US)
Pages (from-to)115-128
Number of pages14
JournalImmunopharmacology and Immunotoxicology
Volume16
Issue number1
DOIs
StatePublished - 1994

Bibliographical note

Funding Information:
This work was supported by grants from FiindacQo de Amparo a Pessliisa do Estado de SPo Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Cientifico E Tecnologico (CNPq).

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