Immunogenetics of posttraumatic stress disorder (PTSD) in women veterans

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric condition that is associated with concomitant immune system dysfunction. Here we evaluated the influence of genes involved in the human immune response, Human Leukocyte Antigen (HLA), on lifetime PTSD in primarily Caucasian women veterans. High-resolution HLA genotyping was completed for 372 participants. We assessed differences in HLA makeup between Control (n = 277) and lifetime PTSD (n = 95) groups. HLA was found to have a significant overall effect on lifetime PTSD occurrence (P < 0.00001). Of the 192 alleles identified in this sample, the frequencies of 15 alleles significantly differed between groups. Two alleles – HLA-A*02:01 and DPB1*04:01 –occurred more frequently in controls, presumably indicating protective effects. Thirteen alleles (6 Class I, 7 Class II) occurred more frequently in the lifetime PTSD group, presumably indicating susceptibility effects. In analysis evaluating the effect of the combined presence in individual participants of a protective allele and a susceptibility allele, the presence of a protective allele neutralized the effect of the susceptibility alleles. These findings, which add to the nascent literature on immunogenetics of PTSD, are discussed in terms of the evolutionary role of HLA in host protection against foreign antigens.

Original languageEnglish (US)
Article number100567
JournalBrain, Behavior, and Immunity - Health
Volume26
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This work was supported US Department of Veterans Affairs (CSRD Merit Review Award I01-CX001045 ) and the University of Minnesota . The sponsors had no role in the current study design, analysis or interpretation, or in the writing of this paper. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.

Funding Information:
Department of Veterans Affairs, CSR&D Merit Review Award (I01-CX001045).This work was supported US Department of Veterans Affairs (CSRD Merit Review Award I01-CX001045) and the University of Minnesota. The sponsors had no role in the current study design, analysis or interpretation, or in the writing of this paper. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.

Publisher Copyright:
© 2022

Keywords

  • Human leukocyte antigen
  • Immunogenetics
  • Posttraumatic stress disorder
  • Veterans
  • Women

PubMed: MeSH publication types

  • Journal Article

Fingerprint

Dive into the research topics of 'Immunogenetics of posttraumatic stress disorder (PTSD) in women veterans'. Together they form a unique fingerprint.

Cite this