Immunochemical identification of the 1,25-dihydroxyvitamin D3 receptor protein in human heart

Timothy D. O'Connell; Robert U. Simpson

doi:10.1006/cbir.1996.0081

Immunochemical identification of the 1,25-dihydroxyvitamin D₃ receptor protein in human heart

Timothy D. O'Connell, Robert U. Simpson

Integrative Biology and Physiology

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A number of recent clinical observations suggest that vitamin D₃ plays an important role in maintaining normal cardiovascular function, either directly through its receptor in cardiac muscle, or indirectly through its influence on circulating levels of calcium or on other regulatory factors. By using an antibody directed against the recombinant vitamin D₃ receptor, we have identified the receptor protein for 1,25(OH)₂D₃ in tissue from two human hearts. The identification of the 1,25(OH)₂D₃ receptor in human heart lends credence to the hypothesis that 1,25(OH)₂D₃ directly effects the human heart and may be involved in several clinically relevant pathological conditions involving the vitamin D₃ endocrine system.

Original language	English (US)
Pages (from-to)	621-624
Number of pages	4
Journal	Cell Biology International
Volume	20
Issue number	9
DOIs	https://doi.org/10.1006/cbir.1996.0081
State	Published - Sep 1996

Bibliographical note

Funding Information:
This work was supported by the American Heart Association and the National Dairy Board in cooperation with the National Dairy Council. *To whom correspondence should be addressed. †Predoctoral fellow: Interdepartmental Training Grant in the Pharmacological Sciences, NIH/NIGMS Grant No. GM07767.

Keywords

Human heart
Receptor
Vitamin D

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Publisher link

10.1006/cbir.1996.0081

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abstract = "A number of recent clinical observations suggest that vitamin D3 plays an important role in maintaining normal cardiovascular function, either directly through its receptor in cardiac muscle, or indirectly through its influence on circulating levels of calcium or on other regulatory factors. By using an antibody directed against the recombinant vitamin D3 receptor, we have identified the receptor protein for 1,25(OH)2D3 in tissue from two human hearts. The identification of the 1,25(OH)2D3 receptor in human heart lends credence to the hypothesis that 1,25(OH)2D3 directly effects the human heart and may be involved in several clinically relevant pathological conditions involving the vitamin D3 endocrine system.",

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