A number of recent clinical observations suggest that vitamin D3 plays an important role in maintaining normal cardiovascular function, either directly through its receptor in cardiac muscle, or indirectly through its influence on circulating levels of calcium or on other regulatory factors. By using an antibody directed against the recombinant vitamin D3 receptor, we have identified the receptor protein for 1,25(OH)2D3 in tissue from two human hearts. The identification of the 1,25(OH)2D3 receptor in human heart lends credence to the hypothesis that 1,25(OH)2D3 directly effects the human heart and may be involved in several clinically relevant pathological conditions involving the vitamin D3 endocrine system.
Bibliographical noteFunding Information:
This work was supported by the American Heart Association and the National Dairy Board in cooperation with the National Dairy Council. *To whom correspondence should be addressed. †Predoctoral fellow: Interdepartmental Training Grant in the Pharmacological Sciences, NIH/NIGMS Grant No. GM07767.
- Human heart
- Vitamin D