Immunobiology of the TAM receptors

Greg Lemke; Carla V. Rothlin

doi:10.1038/nri2303

Immunobiology of the TAM receptors

Greg Lemke
, Carla V. Rothlin

Research output: Contribution to journal › Review article › peer-review

771 Scopus citations

Abstract

Recent studies have revealed that the TAM receptor protein tyrosine kinases - TYRO3, AXL and MER - have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.

Original language	English (US)
Pages (from-to)	327-336
Number of pages	10
Journal	Nature Reviews Immunology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/nri2303
State	Published - May 2008
Externally published	Yes

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10.1038/nri2303

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title = "Immunobiology of the TAM receptors",

abstract = "Recent studies have revealed that the TAM receptor protein tyrosine kinases - TYRO3, AXL and MER - have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.",

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AB - Recent studies have revealed that the TAM receptor protein tyrosine kinases - TYRO3, AXL and MER - have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.

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Immunobiology of the TAM receptors

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