Abstract
The two large open reading frames denoted L1 and L2 in the non-transforming region of the bovine papillomavirus type 1 (BPV-1) genome have been molecularly cloned to expression in Escherichia coli. Antisera against the E. coli-derived L1 and L2 protein reacted with BPV-1 in both enzyme-linked immunosorbent assays and immunoprecipitation reactions. Neutralization of BPV-induced transformation of mouse C127 cells was demonstrated most consistently with antisera against the L1 protein. E. coli-derived L1 protein protected calves against BPV-1 challenge after vaccination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 136-156 |
| Number of pages | 21 |
| Journal | Ciba Foundation symposium |
| Volume | 120 |
| State | Published - Jan 1 1986 |
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Pilacinski, W. P., Glassman, D. L., Glassman, K. F., Reed, D. E., Lum, M. A., Marshall, R. F., Muscoplat, C. C., & Faras, A. J. (1986). Immunization against bovine papillomavirus infection. Ciba Foundation symposium, 120, 136-156.