Immunization against bovine papillomavirus infection.

W. P. Pilacinski, D. L. Glassman, K. F. Glassman, D. E. Reed, M. A. Lum, R. F. Marshall, C. C. Muscoplat, A. J. Faras

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The two large open reading frames denoted L1 and L2 in the non-transforming region of the bovine papillomavirus type 1 (BPV-1) genome have been molecularly cloned to expression in Escherichia coli. Antisera against the E. coli-derived L1 and L2 protein reacted with BPV-1 in both enzyme-linked immunosorbent assays and immunoprecipitation reactions. Neutralization of BPV-induced transformation of mouse C127 cells was demonstrated most consistently with antisera against the L1 protein. E. coli-derived L1 protein protected calves against BPV-1 challenge after vaccination.

Original languageEnglish (US)
Pages (from-to)136-156
Number of pages21
JournalCiba Foundation symposium
StatePublished - 1986


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