Immunity through DNA deamination

Michael S. Neuberger; Reuben S. Harris; Javier Di Noia; Svend K. Petersen-Mahrt

doi:10.1016/S0968-0004(03)00111-7

Immunity through DNA deamination

Michael S. Neuberger, Reuben S. Harris, Javier Di Noia, Svend K. Petersen-Mahrt

Biochemistry, Molecular Biology, and Biophysics (CBS)

Research output: Contribution to journal › Review article › peer-review

98 Scopus citations

Abstract

Functional antibody genes assembled by V(D)J joining are subsequently diversified by somatic hypermutation, gene conversion and class-switch recombination. Recent evidence indicates that all three processes are caused by the deamination of cytosine to uracil at sites within the immunoglobulin (Ig) loci, with the pattern of diversification depending on the pathway used for resolving the initiating dU-dG lesion. Whereas DNA deamination targeted to the endogenous Ig locus triggers a program of somatic gene diversification that underpins adaptive immunity, deamination targeted to foreign DNA might have arisen initially as a form of innate immunity. Furthermore, the observation that members of the DNA deaminase family can target inappropriate genes suggests they might also contribute to mutations during genome evolution, as well as in cancer.

Original language	English (US)
Pages (from-to)	305-312
Number of pages	8
Journal	Trends in Biochemical Sciences
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0004(03)00111-7
State	Published - Jun 1 2003

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abstract = "Functional antibody genes assembled by V(D)J joining are subsequently diversified by somatic hypermutation, gene conversion and class-switch recombination. Recent evidence indicates that all three processes are caused by the deamination of cytosine to uracil at sites within the immunoglobulin (Ig) loci, with the pattern of diversification depending on the pathway used for resolving the initiating dU-dG lesion. Whereas DNA deamination targeted to the endogenous Ig locus triggers a program of somatic gene diversification that underpins adaptive immunity, deamination targeted to foreign DNA might have arisen initially as a form of innate immunity. Furthermore, the observation that members of the DNA deaminase family can target inappropriate genes suggests they might also contribute to mutations during genome evolution, as well as in cancer.",

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AU - Harris, Reuben S.

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AU - Petersen-Mahrt, Svend K.

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AB - Functional antibody genes assembled by V(D)J joining are subsequently diversified by somatic hypermutation, gene conversion and class-switch recombination. Recent evidence indicates that all three processes are caused by the deamination of cytosine to uracil at sites within the immunoglobulin (Ig) loci, with the pattern of diversification depending on the pathway used for resolving the initiating dU-dG lesion. Whereas DNA deamination targeted to the endogenous Ig locus triggers a program of somatic gene diversification that underpins adaptive immunity, deamination targeted to foreign DNA might have arisen initially as a form of innate immunity. Furthermore, the observation that members of the DNA deaminase family can target inappropriate genes suggests they might also contribute to mutations during genome evolution, as well as in cancer.

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Immunity through DNA deamination

Abstract

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