Immune response by microglia in the spinal cord

Research output: Chapter in Book/Report/Conference proceedingConference contribution

32 Scopus citations

Abstract

Microglia are the resident immune cells of the central nervous system (CNS) and share many immunological characteristics with peripheral macrophage. Microglia exist in a quiescent state in the healthy CNS, however, upon injury or infection, microglia become activated immune cells. Microglia have been implicated in playing an important role in several neurological diseases that affect the spinal cord, especially multiple sclerosis (MS) and neuropathic pain. However, most studies, which examined the immune response by microglia have been conducted using microglia cultures generated from brain microglia. Therefore, our studies examined the immune response by microglia in the spinal cord compared to the immune response by microglia in the brain. Microglia in the spinal cord of mice expressed higher levels of surface immune molecules than microglia in the brain, and upon virus infection, microglia in the spinal cord expressed higher levels of immune molecules than microglia in the brain. These studies suggest that microglia in the spinal cord may have different immune reactivity than microglia in the brain, which may contribute to spinal cord diseases.

Original languageEnglish (US)
Title of host publicationNeurons and Networks in the Spinal Cord
PublisherBlackwell Publishing Inc
Pages271-278
Number of pages8
ISBN (Print)9781573317788
DOIs
StatePublished - Jun 2010
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1198
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • microglia
  • neuroimmunology
  • rodent
  • virus infection

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