Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Amy M Linabery, Wenchao Li, Michelle A Roesler, Logan G. Spector, Alan S Gamis, Andrew F Olshan, Nyla A. Heerema, Julie A. Ross

Research output: Book/ReportBook


BACKGROUND: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.\n\nMETHODS: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.\n\nRESULTS: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.\n\nCONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.
Original languageEnglish (US)
ISBN (Electronic)1538-7755
StatePublished - 2015


  • Adolescent
  • Child
  • Child, Preschool
  • Diabetes Mellitus
  • Diabetes Mellitus: etiology
  • Down Syndrome
  • Down Syndrome: complications
  • Female
  • Humans
  • Immune System Diseases
  • Immune System Diseases: etiology
  • Immune System Diseases: immunology
  • Infant
  • Infant, Newborn
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid, Acute: etiology
  • Leukemia, Myeloid, Acute: immunology
  • Logistic Models
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma: et
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma: im
  • Risk Factors
  • Young Adult


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