Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Amy M Linabery, Wenchao Li, Michelle A Roesler, Logan G. Spector, Alan S Gamis, Andrew F Olshan, Nyla A. Heerema, Julie A. Ross

Research output: Book/ReportBook

Abstract

BACKGROUND: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.\n\nMETHODS: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.\n\nRESULTS: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.\n\nCONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.
Original languageEnglish (US)
Volume24
ISBN (Electronic)1538-7755
StatePublished - 2015

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Down Syndrome
Leukemia
Eczema
Hypothyroidism
Diabetes Mellitus
Hypersensitivity
Asthma
Logistic Models
Mothers
Confidence Intervals

Keywords

  • Adolescent
  • Child
  • Child, Preschool
  • Diabetes Mellitus
  • Diabetes Mellitus: etiology
  • Down Syndrome
  • Down Syndrome: complications
  • Female
  • Humans
  • Immune System Diseases
  • Immune System Diseases: etiology
  • Immune System Diseases: immunology
  • Infant
  • Infant, Newborn
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid, Acute: etiology
  • Leukemia, Myeloid, Acute: immunology
  • Logistic Models
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma: et
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma: im
  • Risk Factors
  • Young Adult

Cite this

Linabery, A. M., Li, W., Roesler, M. A., Spector, L. G., Gamis, A. S., Olshan, A. F., ... Ross, J. A. (2015). Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report. / Linabery, Amy M; Li, Wenchao; Roesler, Michelle A; Spector, Logan G.; Gamis, Alan S; Olshan, Andrew F; Heerema, Nyla A.; Ross, Julie A.

2015.

Research output: Book/ReportBook

Linabery, AM, Li, W, Roesler, MA, Spector, LG, Gamis, AS, Olshan, AF, Heerema, NA & Ross, JA 2015, Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report. vol. 24.
Linabery, Amy M ; Li, Wenchao ; Roesler, Michelle A ; Spector, Logan G. ; Gamis, Alan S ; Olshan, Andrew F ; Heerema, Nyla A. ; Ross, Julie A. / Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report. 2015.
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abstract = "BACKGROUND: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.\n\nMETHODS: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.\n\nRESULTS: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95{\%} confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.\n\nCONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.",
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author = "Linabery, {Amy M} and Wenchao Li and Roesler, {Michelle A} and Spector, {Logan G.} and Gamis, {Alan S} and Olshan, {Andrew F} and Heerema, {Nyla A.} and Ross, {Julie A.}",
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AU - Roesler, Michelle A

AU - Spector, Logan G.

AU - Gamis, Alan S

AU - Olshan, Andrew F

AU - Heerema, Nyla A.

AU - Ross, Julie A.

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AB - BACKGROUND: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.\n\nMETHODS: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.\n\nRESULTS: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.\n\nCONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

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