Immune-related conditions and acute leukemia in children with down syndrome: A children's oncology group report

Amy M. Linabery, Wenchao Li, Michelle A. Roesler, Logan G. Spector, Alan S. Gamis, Andrew F. Olshan, Nyla A. Heerema, Julie A. Ross

Research output: Contribution to journalArticle

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Abstract

Background: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.

Methods: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.

Results: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.

Conclusions and Impact: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

Original languageEnglish (US)
Pages (from-to)454-458
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2015

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Down Syndrome
Leukemia
Eczema
Hypothyroidism
Diabetes Mellitus
Hypersensitivity
Asthma
Logistic Models
Mothers
Confidence Intervals

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Immune-related conditions and acute leukemia in children with down syndrome : A children's oncology group report. / Linabery, Amy M.; Li, Wenchao; Roesler, Michelle A.; Spector, Logan G.; Gamis, Alan S.; Olshan, Andrew F.; Heerema, Nyla A.; Ross, Julie A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 24, No. 2, 01.02.2015, p. 454-458.

Research output: Contribution to journalArticle

Linabery, Amy M. ; Li, Wenchao ; Roesler, Michelle A. ; Spector, Logan G. ; Gamis, Alan S. ; Olshan, Andrew F. ; Heerema, Nyla A. ; Ross, Julie A. / Immune-related conditions and acute leukemia in children with down syndrome : A children's oncology group report. In: Cancer Epidemiology Biomarkers and Prevention. 2015 ; Vol. 24, No. 2. pp. 454-458.
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AU - Heerema, Nyla A.

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