As new Ag-specific and non-Ag-specific mechanisms contributing to ocular immune privilege are revealed, the relevance of old paradigms properly comes into question. My lab has a particular interest in the immune privilege of the retina. While the presence of active mechanisms of tolerance, such as immune deviation, is now well-established, we propose that sequestration provides the first line of immune privilege in the retina. When it fails, active, inducible mechanisms provide backup to protect the integrity of the retina and vision. Some of the observations that led to our hypotheses and their supporting experiments are discussed below.
Bibliographical noteFunding Information:
Dale S. Gregerson, Ph.D., Prof. Department of Ophthalmology Lions Research Building, Rm. 314 University of Minnesota 2001 6th Street SE Minneapolis, MN 55455-3007 USA Tel: 612-626-0772 Fax: 612-626-0781 e-mail: email@example.com Acknowledgements: The author thanks Drs. Gary Birnbaum, Robert Hendricks, Shiv Prasad, and Beth Frenzel for their critiques of the manuscript. This work was supported by NIH grant EY11542, Research to Prevent Blindness, Inc., the Anna Heilmaier Foundation, and the Minnesota Lions and Lionesses Clubs.
- Immune tolerance