Immune Complexes and the Treatment of Biliary Cirrhosis

Ronald D Soltis, I. Dodd Wilson, Robert H. Resnick, Owen Epstein, Howard Thomas

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


To the Editor: In the February 8 issue of the Journal, Epstein and his associates reported that immune-complex activity in the serums of patients with primary biliary cirrhosis diminished during treatment with penicillamine, and followed improvement in biochemical variables and a decrease in serum IgM concentrations.1 We suggest that immune complexes in primary biliary cirrhosis probably do not have a major pathogenic role in bile-duct destruction but, rather, that they simply represent IgM aggregated in vivo as a result of increased serum IgM concentrations. Immunoglobulin aggregates, produced by heating at 60° to 63°C, cannot be distinguished from true antigen–antibody.

Original languageEnglish (US)
Pages (from-to)1487-1488
Number of pages2
JournalNew England Journal of Medicine
Issue number26
StatePublished - Jun 28 1979


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