Immune cell neural interactions and their contributions to sickle cell disease

Varun Sagi, Aditya Mittal, Mihir Gupta, Kalpna Gupta

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain. Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of how the nervous and immune systems interact to contribute to pain and other comorbidities in SCD. Sterile inflammation in the periphery and central nervous system contributes to vascular and neural activation. Cellular and soluble mediators create an inflammatory and neuroinflammatory microenvironment contributing to neurogenic inflammation and acute and chronic pain. In this review we highlight relevant neuro-immune interactions that contribute to the pathobiology of SCD.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalNeuroscience Letters
Volume699
DOIs
StatePublished - Apr 23 2019

Bibliographical note

Funding Information:
This work was supported by UO1 HL117664 grant from the National Heart, Lung, and Blood Institute .

Publisher Copyright:
© 2019

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Inflammation
  • Mast cells
  • Pain
  • Serpins
  • Sickle cell disease

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