Immobilization increases bone prostaglandin e: Effect of acetylsalicylic acid on disuse osteoporosis studied in dogs

David J. Waters, Dennis D. Caywood, George J. Trachte, Russell T. Turner, Stephen F. Hodgson

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29 Scopus citations

Abstract

Compared with the controls, the casted limb of untreated dogs had half the bone mass and a twofold increase in bone PGE. Aspirin treatment was associated with a 65 percent reduction in bone PGE and a 13 percent bone mass sparing effect. These results provide indirect evidence that PGE plays a role in immobilization osteoporosis. the effect of acetylsalicylic acid (aspirin) on bone mass and bone prostaglandin E (PGE) in immobilization osteoporosis was studied in 12 growing dogs using a unilateral hind limb castfixation model. Osteoporosis was induced by fiberglass-cast immobilization of the right hind limb for 4 weeks, with the left hind limb as a control. Six dogs received buffered aspirin at 25 mg/kg body weight per os every 8 hours; 6 dogs received no treatment. All the dogs were killed after 4 weeks, and bone samples were collected. Bone mineral content of the distal tibial metaphysis was measured by single-photon absorptiometry. In vitro release of PGE from the calcaneus, tibial cortical bone, tibial cancellous bone, and ilium were measured using a specific radioimmunoassay for PGE.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalActa orthopaedica
Volume62
Issue number3
DOIs
StatePublished - 1991

Bibliographical note

Funding Information:
This project was supported by the Biomedical Research Investigation Fund, College of Veterinary Medicine, University of Minnesota, and NIH Grant AR 35651 (RTT).

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