Imidocarb dipropionate in the treatment of Anaplasma marginale in cattle: Effects on enzymes of the antioxidant, cholinergic, and adenosinergic systems

Rovaina L. Doyle, Alexandro Fritzen, Nathieli B. Bottari, Mariana S. Alves, Aniélen D. da Silva, Vera M. Morsch, Maria Rosa C. Schetinger, João R. Martins, Julsan S. Santos, Gustavo Machado, Aleksandro S. da Silva

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Anaplasmosis is a worldwide hemolytic disease in cattle caused by a gram-negative obligatory intracellular bacterium, characterized by anemia and jaundice. Among the treatments used for anaplasmosis is a drug called imidocarb dipropionate, also indicated as an immunomodulator agent. However, it causes side effects associated with increased levels of acetylcholine. In view of this, the effects of imidocarb dipropionate on the purinergic system, and antioxidant enzymes in animals naturally infected by Anaplasma marginale were evaluated. Young cattle (n = 22) infected by A. marginale were divided into two groups: the Group A consisted of 11 animals used as controls; and the Group B composed of 11 animals. Imidocarb dipropionate (5 mg/kg) was used subcutaneously to treat both groups (the Group A on day 6 and the Group B on day 0). The treatment reduced acetylcholinesterase (AChE), and adenosine deaminase (ADA) activities, and increased the dismutase superoxide and catalase activities. No changes on lipid peroxidation (TBARS levels) and BChE activities were noticed. These results suggest that imidocarb dipropionate used to treat A. marginale infection in cattle has effect on antioxidant enzymes, and significantly inhibits the enzymatic activities of ADA and AChE.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalMicrobial Pathogenesis
Volume97
DOIs
StatePublished - Aug 1 2016

Bibliographical note

Publisher Copyright:
© 2016

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • AChE
  • ADA
  • Anaplasma marginale
  • CAT
  • Immunomodulation
  • SOD

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