Imaging the cardiac extracellular matrix

Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Cardiovascular disease is the global leading cause of death. One route to address this problem is using biomedical imaging to measure the molecules and structures that surround cardiac cells. This cellular microenvironment, known as the cardiac extracellular matrix, changes in composition and organization during most cardiac diseases and in response to many cardiac treatments. Measuring these changes with biomedical imaging can aid in understanding, diagnosing, and treating heart disease. This chapter supports those efforts by reviewing representative methods for imaging the cardiac extracellular matrix. It first describes the major biological targets of ECM imaging, including the primary imaging target of fibrillar collagen. Then it discusses the imaging methods, describing their current capabilities and limitations. It categorizes the imaging methods into two main categories: organ-scale noninvasive methods and cellular-scale invasive methods. Noninvasive methods can be used on patients, but only a few are clinically available, and others require further development to be used in the clinic. Invasive methods are the most established and can measure a variety of properties, but they cannot be used on live patients. Finally, the chapter concludes with a perspective on future directions and applications of biomedical imaging technologies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages21-44
Number of pages24
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1098
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Funding Information:
We thank Brenda Ogle and Ellen Arena for useful input. We also acknowledge funding from the Laboratory for Optical and Computational Instrumentation, the Morgridge Institute for Research, NIH R01 HL137204 (RAH), NIH R01 131017 (RAH), NIH T32 CA009206 (MAP), and the NIH T32 GM008349 (MAP). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation.

Funding Information:
Acknowledgment We thank Brenda Ogle and Ellen Arena for useful input. We also acknowledge funding from the Laboratory for Optical and Computational Instrumentation, the Morgridge Institute for Research, NIH R01 HL137204 (RAH), NIH R01 131017 (RAH), NIH T32 CA009206 (MAP), and the NIH T32 GM008349 (MAP). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Science Foundation.

Keywords

  • Cardiac
  • Collagen
  • Composition
  • Extracellular matrix
  • Fibers
  • Imaging

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